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N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide

Name: N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

C2-8

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₁₄Br₂N₂O₃S

CAS Number:

300670-16-0

Molecular Weight:

510.20

NACRES:

NA.77

PubChem Substance ID:

24724418

UNSPSC Code:

12352200

MDL number:

MFCD00355835

Assay:

≥98% (HPLC)

Form:

solid

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Properties

Quality Segment

100

assay

≥98% (HPLC)

form

solid

color

off-white

solubility

DMSO: ~20 mg/mL, H₂O: insoluble

storage temp.

2-8°C

SMILES string

Brc1ccc(NC(=O)c2cccc(c2)S(=O)(=O)Nc3ccc(Br)cc3)cc1

InChI

1S/C19H14Br2N2O3S/c20-14-4-8-16(9-5-14)22-19(24)13-2-1-3-18(12-13)27(25,26)23-17-10-6-15(21)7-11-17/h1-12,23H,(H,22,24)

InChI key

SJJKUNDBFWUAQB-UHFFFAOYSA-N

Description

Biochem/physiol Actions

N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl] benzamide is the first inhibitor of aggregation of the polyglutamine (polyQ) sequence of the Huntington′s Disease protein (huntingtin).

N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide is the first inhibitor of aggregation of the polyglutamine (polyQ) sequence of the Huntington′s Disease protein (huntingtin); polyQ aggregation is neurotoxic, and inhibitors of aggregation may be therapeutic in HD and other polyQ diseases; C2-8 inhibited aggregation in HD PC12 cells with an IC50 of 50nM; when administered in food, suppressed neurodegeneration in vivo in the Drosophila HD model.

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This Item	P0618	S4443	C3118
Sigma-Aldrich B3436 N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide	Sigma-Aldrich P0618 cis-8-Hydroxy-3-(n-propyl)-1,2,3a,4,5,9b-hexahydro-1H-benz[e]indole hydrobromide	Sigma-Aldrich S4443 SCH-28080	Sigma-Aldrich C3118 CPNQ
form solid	form solid	form solid	form solid
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level -	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C
solubility DMSO: ~20 mg/mL, H₂O: insoluble	solubility H₂O: soluble ~10 mg/mL at 60 °C (Sonicate), DMSO: soluble 12 mg/mL	solubility DMSO: soluble >10 mg/mL, H₂O: insoluble	solubility H₂O: insoluble <2 mg/mL, DMSO: >5 mg/mL
color off-white	color light brown	color white to light tan	color brown

pictograms

GHS07

signalword

Warning

hcodes

H319,H413

pcodes

P273 - P305 + P351 + P338

Hazard Classifications

Aquatic Chronic 4 - Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

016K4622

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Global Trade Item Number

SKU	GTIN
B3436-25MG	04061832269320
B3436-5MG	04061832977102

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