A9106
ADP-ribosylcyclase
1000-3000 units/mg protein
Synonym(s):
Adenosine diphosphoribose cyclase from Aplysia californica
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About This Item
Specific activity:
1000-3000 units/mg protein
Assay:
≥80 μ protein/vial (BCA)
Biological source:
(Aplysia californica)
Concentration:
≤10% (BCA method)
Pricing and availability is not currently available.
biological source
(Aplysia californica)
Quality Level
assay
≥80 μ protein/vial (BCA)
form
lyophilized powder
specific activity
1000-3000 units/mg protein
composition
Protein, ≤10%
packaging
vial of ≥80 μg protein
storage condition
dry at room temperature
concentration
≤10% (BCA method)
suitability
suitable for enzyme test
application(s)
genomic analysis
storage temp.
−20°C
Application
ADP-ribosylcyclase is a Ca2+ signaling second messenger. It may be used to study calcium signaling and has been used to research morphine antinociception and tolerance [1].
Biochem/physiol Actions
ADP-ribosylcyclase is an intracellular calcium regulator that cyclizes NAD into cADPR. It is thought that the majority of ADP-ribosylcyclase activity in the brain is linked to CD38. Nicotinamide is a known inhibitor of CD38 ADP-ribosylcyclase activity [1].
Physical form
Lyophilized powder containing trehalose, potassium phosphate and dithiothreitol
Other Notes
One unit will produce 1 μmole of cyclic ADP ribose from β-NAD+ in 5 minutes at pH 7.0 and 25°C.
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This Item | |||
|---|---|---|---|
| assay ≥80 μ protein/vial (BCA) | assay - | assay - | assay - |
| biological source (Aplysia californica) | biological source - | biological source potato | biological source - |
| specific activity 1000-3000 units/mg protein | specific activity - | specific activity - | specific activity - |
| form lyophilized powder | form lyophilized powder | form lyophilized powder | form lyophilized powder |
| suitability suitable for enzyme test | suitability - | suitability - | suitability - |
| concentration ≤10% (BCA method) | concentration - | concentration - | concentration - |
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Heather S Loring et al.
Biochemistry, 59(8), 933-942 (2020-02-13)
Sterile alpha and toll/interleukin receptor (TIR) motif-containing protein 1 (SARM1) plays a pivotal role in triggering the neurodegenerative processes that underlie peripheral neuropathies, traumatic brain injury, and neurodegenerative diseases. Importantly, SARM1 knockdown or knockout prevents degeneration, thereby demonstrating that SARM1
Lynn C Hull et al.
The Journal of pharmacology and experimental therapeutics, 334(3), 1042-1050 (2010-06-17)
Our previous studies have demonstrated that an increase in intracellular levels of Ca(2+) in neurons is an important component of both the antinociception produced by morphine and morphine's tolerance. The present study tested the hypothesis that the Ca(2+) signaling second
Xiaojian Shao et al.
Nature protocols, 15(9), 2813-2836 (2020-08-05)
Several noncanonical initial nucleotides (NCINs) have been found to cap RNAs and possibly regulate RNA stability, transcription and translation. NAD+ is one of the NCINs that has recently been discovered to cap RNAs in a wide range of species. Identification
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A9106-1VL | 04061826588932 |