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Angiotensin IV trifluoroacetate salt

Name: Angiotensin IV trifluoroacetate salt
Brand: SIGMA

≥95% (HPLC), powder

Synonym(s):

Ang IV, Angiotensin II (3-8)

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About This Item

Empirical Formula (Hill Notation):

C₄₀H₅₄N₈O₈ · xC₂HF₃O₂

CAS Number:

12676-15-2

Molecular Weight:

774.91 (free base basis)

NACRES:

NA.77

PubChem Substance ID:

329770587

UNSPSC Code:

12352200

MDL number:

MFCD00167496

Assay:

≥95% (HPLC)

Form:

powder

Quality level:

100

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Properties

Quality Level

100

assay

≥95% (HPLC)

form

powder

color

white

solubility

H₂O: ~1 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(O)=O

InChI

1S/C40H54N8O8/c1-5-24(4)34(47-35(50)29(44-37(52)33(41)23(2)3)18-26-13-15-28(49)16-14-26)38(53)45-30(20-27-21-42-22-43-27)39(54)48-17-9-12-32(48)36(51)46-31(40(55)56)19-25-10-7-6-8-11-25/h6-8,10-11,13-16,21-24,29-34,49H,5,9,12,17-20,41H2,1-4H3,(H,42,43)(H,44,52)(H,45,53)(H,46,51)(H,47,50)(H,55,56)/t24-,29-,30-,31-,32-,33-,34-/m0/s1

InChI key

QSBGWDDCOJYQGY-KOQODJNWSA-N

Description

Biochem/physiol Actions

AT₄ angiotensin receptor agonist.

AT₄ angiotensin receptor agonist. The AT₄receptor appears to be important in synaptic plasticity and thus in learning and memory.

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This Item	SML1374	10385	SML0395
Sigma-Aldrich A0230 Angiotensin IV trifluoroacetate salt	Sigma-Aldrich SML1374 Alamandine trifluoroacetate salt	Sigma-Aldrich 10385 Angiotensin III trifluoroacetate salt hydrate	Sigma-Aldrich SML0395 Ac-EEMQRR-NH2 trifluoroacetate salt
form powder	form powder	form -	form lyophilized solid
assay ≥95% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPCE)	assay ≥95% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
solubility H₂O: ~1 mg/mL	solubility -	solubility H₂O: 1.0 mg/mL, clear, colorless	solubility -
color white	color white to beige	color -	color white

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Alzheimer's, angiotensin IV and an aminopeptidase.

Anthony Lloyd Albiston et al.

Biological & pharmaceutical bulletin, 27(6), 765-767 (2004-06-10)

The angiotensin AT(4) receptor was originally defined as the specific, high affinity binding site for the hexapeptide angiotensin IV (Ang IV). Subsequently, the peptide LVV-hemorphin 7 was also demonstrated to be a bioactive ligand of the AT(4) receptor. Central administration

Angiotensin II-(3-8)-hexapeptide affects motor activity, performance of passive avoidance and a conditioned avoidance response in rats.

J J Braszko et al.

Neuroscience, 27(3), 777-783 (1988-12-01)

Angiotensin II-(3-8)-hexapeptide, at the dose of 1 nmol given intracerebroventricularly, only slightly less than angiotensin II (the same dose and route) stimulated exploratory locomotor behaviour in an open field and electromagnetic motimeter. Both peptides considerably enhanced stereotyped behaviour produced by

Identification and characterization of a novel angiotensin binding site in cultured vascular smooth muscle cells that is specific for the hexapeptide (3-8) fragment of angiotensin II, angiotensin IV.

K L Hall et al.

Regulatory peptides, 44(2), 225-232 (1993-03-19)

This study demonstrates the existence of a previously unrecognized class of angiotensin binding sites on vascular smooth muscle that exhibit high affinity and specificity for the hexapeptide (3-8) fragment of angiotensin II (AngIV). Binding of [125I]AngIV is saturable, reversible and

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Global Trade Item Number

SKU	GTIN
A0230-1MG	04061833327142

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