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53471

FITC-CM-Dextran

average mol wt 70,000

Synonym(s):

FITC-CM-Dextran 70, Fluorescein isothiocyanate–Carboxymethyl–Dextran

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About This Item

NACRES:
NA.32
UNSPSC Code:
12352116
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conjugate

FITC conjugate

Quality Segment

form

powder or crystals

mol wt

average mol wt 70,000

composition

carboxymethyl content, 3-7%

extent of labeling

0.001-0.020 mol/mol FITC glucose

technique(s)

permeability assay: suitable

fluorescence

λex 493 nm; λem 517 nm±5 nm in 0.1 M Tris pH 8.0

General description

FITC-CM-Dextran, also known as Fluorescein isothiocyanate–Carboxymethyl–Dextran, is an anionic fluorescent probe. The carboxyl group provides the negative charge, which improves the overall permeability of the molecule. It is supplied as a yellow powder that is freely soluble in water and electrolyte solutions. FITC-CM-Dextran is insoluble in most organic samples such as ethanol, methanol, acetone, and chloroform. FITC-CM-Dextran is manufactured by reacting selected dextran fractions with an activated carboxymethyl derivative in alkali, whereby O-carboxymethyl groups are introduced along the dextran chain.

Application

FITC-CM-dextran is used to study drug intake and delivery mechanisms in HeLa cell lines. FITC-CM-Dextran was chosen due to its high water solubility and negative charge.[1] It is also a suitable molecule to be used in encapsulation studies for polymersomal drug delivery systems or Ps DDS.[2] FITC-CM-Dextran is a biocompatible molecule used as a starting material in several pharmaceutical and diagnostic applications.

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This Item
680597481790718
technique(s)

permeability assay: suitable

technique(s)

permeability assay: suitable

technique(s)

-

technique(s)

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

form

powder or crystals

form

powder or crystals

form

powder or crystals

form

powder or crystals

extent of labeling

0.001-0.020 mol/mol FITC glucose

extent of labeling

0.001-0.020 mol/mol FITC glucose

extent of labeling

0.001-0.020 mol FITCmol glucose

extent of labeling

0.001-0.020 mol/mol FITC glucose

fluorescence

λex 493 nm; λem 517 nm±5 nm in 0.1 M Tris pH 8.0

fluorescence

λex 493 nm; λem 517 nm±5 nm in 0.1 M Tris pH 8.0

fluorescence

λex 493 nm; λem 517 nm±5 nm in 0.1 M Tris pH 8.0

fluorescence

λex 493 nm; λem 520 nm±5 nm in 0.1 M Tris pH 8.0

conjugate

FITC conjugate

conjugate

FITC conjugate

conjugate

FITC conjugate

conjugate

FITC conjugate


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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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Global Trade Item Number

SKUGTIN
53471-1G04061826643464

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