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A115

Amitriptyline metabolite, (±)-E-10-hydroxylated-

analytical standard

Synonym(s):

(±)-(E)-5-[3-(Dimethylamino)propylidene]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-ol

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About This Item

Empirical Formula (Hill Notation):
C20H23NO
CAS Number:
64520-05-4
Molecular Weight:
293.40
NACRES:
NA.24
PubChem Substance ID:
329770681
UNSPSC Code:
41116107
MDL number:
MFCD00069200
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Quality Level

200

grade

analytical standard

form

solid

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

color

white

mp

97-99 °C

solubility

0.1 M HCl: soluble, H2O: insoluble, methanol: soluble

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

CN(C)CC\C=C1/c2ccccc2CC(O)c3ccccc13

InChI

1S/C20H23NO/c1-21(2)13-7-12-17-16-9-4-3-8-15(16)14-20(22)19-11-6-5-10-18(17)19/h3-6,8-12,20,22H,7,13-14H2,1-2H3/b17-12+

InChI key

GHWBJXOKAFHZAI-SFQUDFHCSA-N

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Metabolite of amitriptyline, tricyclic antidepressant; chromatographic standard.

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This Item
SMB00969PHR13841029013
Amitriptyline metabolite, (±)-E-10-hydroxylated- analytical standard

Supelco

A115

Amitriptyline metabolite, (±)-E-10-hydroxylated-

(E)-10-Hydroxy amitriptyline ≥95% (HPLC)

Sigma-Aldrich

SMB00969

(E)-10-Hydroxy amitriptyline

Amitriptyline hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1384

Amitriptyline hydrochloride

Amitriptyline Related Compound A United States Pharmacopeia (USP) Reference Standard

USP

1029013

Amitriptyline Related Compound A

grade

analytical standard

grade

-

grade

certified reference material, pharmaceutical secondary standard

grade

pharmaceutical primary standard

format

neat

format

-

format

neat

format

neat

color

white

color

white to yellow

color

-

color

-

form

solid

form

solid

form

-

form

-

Quality Level

200

Quality Level

200

Quality Level

300

Quality Level

-

mp

97-99 °C

mp

-

mp

-

mp

32-34 °C (lit.)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
FN10182301
FN04232005
FN06022219

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X Zhang
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry, 25(4), 196-198 (1992-08-01)
The serum concentrations of amitriptyline and its 3 metabolites--nortriptyline, 10-hydroxy-amitriptyline and 10-hydroxy-nortriptyline were determined in 18 depressive patients treated with amitriptyline for 6 weeks. The relationships between the serum concentrations and the clinical effects were statistically analyzed and showed significant
U Breyer-Pfaff et al.
Clinical pharmacology and therapeutics, 52(4), 350-358 (1992-10-01)
In 26 hospitalized patients with depression, a combined pharmacogenetic test with dextromethorphan, a substrate of cytochrome P450IID6, and mephenytoin, the S-form of which is hydroxylated by a P450IIC isozyme, was carried out before amitriptyline therapy. Metabolites were determined in 24-hour
F Coudoré et al.
Fundamental & clinical pharmacology, 8(6), 525-531 (1994-01-01)
Kinetics of amitriptyline (AMI), its demethylated metabolites nortriptyline (NOR) and demethylnortriptyline (DM-NOR), and its hydroxylated metabolites, the E and Z isomers or 10-hydroxy-amitriptyline (E- and Z-10-OH-AMI) and of 10-hydroxynortriptyline (E- and Z-10-OH-NOR) were studied in plasma and brain from Swiss
View All Related Papers

Global Trade Item Number

SKUGTIN
A115-2MG04061833646144

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