Antibody OP80 and MABC200 are of the same clone. Despite differences in purification method and formulations, the reactive species are expected to be the same.
MABC200
Anti-APC Antibody, clone CC-1
clone CC-1, from mouse
Synonym(s):
Adenomatous polyposis coli protein, APC, Deleted in polyposis 2.5
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
CC-1, monoclonal
Application:
IHC
Citations:
31
Pricing and availability is not currently available.
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
CC-1, monoclonal
species reactivity
human
technique(s)
immunohistochemistry: suitable
isotype
IgG2bκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... APC(324)
General description
311 kDa calculated
Adenomatous polyposis coli protein (APC) is a ubiquitous multidomain protein that has a well documented role as a tumor suppressor. The mechanism of APC-mediated tumor suppression is still an area of active investigation; however, several studies suggest that APC is a negative regulator of the Wnt signaling pathway as it downregulates β-catenin via interactions with Axin/GSK3-β complex, thereby preventing transcription of genes such as MYC that contribute to cell proliferation. Defective APC proteins contribute to the initiation and proliferation of various types of cancers, including familial adenomatous polyposis. However, other studies have shown that APC interacts with a range of other proteins such as the EB1 microtubule-binding proteins, to regulate other processes such as cell migration.
Immunogen
Recombinant protein corresponding to human APC.
Application
Anti-APC Antibody, clone CC-1 detects levels of APC proteins & has been published & validated for use in IHC.
Immunohistochemistry Analysis: A representative lot from an independent laboratory detected APC in human brain tissue containing multiple schlerosis lesions (Saikali, P. et al. (2007). J Neurosci. 27(5):1220-1228.).
Immunohistochemistry Analysis: A representative lot from an independent laboratory detected APC in rat spinal cord injury tissue (McTique, D. M., et al. (2001). J Neurosci. 21(10):3392-3400.).
Immunohistochemistry Analysis: A representative lot from an independent laboratory detected APC in rat spinal cord injury tissue (McTique, D. M., et al. (2001). J Neurosci. 21(10):3392-3400.).
Physical form
Format: Purified
Analysis Note
Immunohistochemistry Analysis: A 1:5 dilution from a representative lot detected APC in human colorectal cancer tissue, human smooth muscle tissue, and human colon tissue.
1 of 1
This Item | |||
|---|---|---|---|
| clone CC-1, monoclonal | clone 3E2, monoclonal | clone polyclonal | clone monoclonal |
| antibody form purified immunoglobulin | antibody form purified immunoglobulin | antibody form affinity isolated antibody | antibody form - |
| Gene Information human ... APC(324) | Gene Information human ... APC(324) | Gene Information human ... APC(324) | Gene Information human ... APC(324) |
| biological source mouse | biological source mouse | biological source rabbit | biological source rabbit |
| species reactivity human | species reactivity human | species reactivity human | species reactivity - |
| conjugate unconjugated | conjugate unconjugated | conjugate unconjugated | conjugate unconjugated |
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| MABC200 | 04053252522062 |
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I would like to perform an IHC on frozen mouse tissue samples and had initially chosen another one of your products (product n OP80). Is this antibody a valid substitute? Is it suitable for mouse samples?
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