This product is stable in 4 degree C for at least 2 weeks. Freeze-thaw cycles should be kept to a minimum. Up to three cycles have been performed without any detectable loss of activity. To further protect product integrity, aliquoting the material is recommended to avoid repeated freezing and thawing. Please see the link below to review additional information available in the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/991/950/dpp4-insert.pdf
DPP4-M
DPP IV Inhibitor
Synonym(s):
DPP IV Inhibitor, Dipeptidyl peptidase 4 Inhibitor, Gliptins
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About This Item
UNSPSC Code:
41116012
NACRES:
NC.07
eCl@ss:
32160405
Pricing and availability is not currently available.
form
solution
Quality Segment
NCBI accession no.
UniProt accession no.
Gene Information
human ... DPP4(1803)
General description
Dipeptidyl peptidase IV (DPP IV), a dimeric type II integral membrane glycoprotein, is a member of the family of prolyl-specific proteases. It is abundantly expressed in the epithelial and nonepithelial tissues. It is highly expressed in the kidney and the colon.[1]
Application
Research Category
All
All
Biochem/physiol Actions
Dipeptidyl peptidase IV (DPP IV) controls insulin-stimulating hormones, glucagon-like peptide (GLP-1), and glucose-dependent insulinotropic polypeptide (GIP). It′s a promising therapeutic target for type 2 diabetes (T2DM).[2] In addition to its catalytic action, DPP-4 also serves as a binding protein and a ligand of extracellular factors.[3] DPP-4 inhibition causes GLP-1 and GIP to have a prolonged activity, hence DPP-4 inhibitors help maintain glucose homeostasis. DPP IV inhibitors can improve glycemic control for a longer period when compared to early oral hypoglycemics.[4]
Preparation Note
Upon arrival, store at 4°C. For long-term of more than 2 weeks, store at –20°C.
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| Gene Information human ... DPP4(1803) | Gene Information - | Gene Information - | Gene Information - |
| Quality Level 100 | Quality Level 200 | Quality Level 100 | Quality Level 100 |
| form solution | form solid | form amorphous solid | form solid |
| UniProt accession no. | UniProt accession no. - | UniProt accession no. - | UniProt accession no. - |
| NCBI accession no. | NCBI accession no. - | NCBI accession no. - | NCBI accession no. - |
Certificates of Analysis (COA)
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Related Content
Global Trade Item Number
| SKU | GTIN |
|---|---|
| DPP4 | 04053252362330 |
| DPP4-010 | 04053252366000 |
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What is the stability of this compound at 4C? How many freeze thaws can it tolerate?
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Would our lab be able to store this product at -80 degrees celsius without compromising its composition?
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It is recommended to store this product at -20°C. The long term stability of this product at -80°C has not been determined. However, there are no issues anticipated by storing this material at ultra-low temperatures.
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What is the concentration of this product and what is the working concentration suggested? Thanks!
1 answer-
This product as provided at a concentration of 4 mM. The working concentration recommendations are 10 μl/mL of whole blood or 20 μl/mL of buffer, plasma, serum, or tissue culture medium. These are general usage recommendations, the optimal concentration is application- and/or system-dependent. The final working concentration should be empirically determined by the end user.
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