218745

Caspase Inhibitor III

The Caspase Inhibitor III, also referenced under CAS 634911-80-1, controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications.

• Synonym(s): Caspase Inhibitor III, Boc-D-FMK
• Empirical Formula (Hill Notation): C₁₁H₁₈FNO₅
• CAS Number: 634911-80-1
• Molecular Weight: 263.26
• MDL number: MFCD04038181
• UNSPSC Code: 12352200
• NACRES: NA.77
• Form: semisolid
• Storage condition: OK to freeze, desiccated

Properties

• Quality Segment: 100
• form: semisolid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated
• color: off-white
• solubility: DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: FCC(=O)C(NC(=O)OC(C)(C)C)CC(=O)OC
• InChI: 1S/C11H18FNO5/c1-11(2,3)18-10(16)13-7(8(14)6-12)5-9(15)17-4/h7H,5-6H2,1-4H3,(H,13,16)
• InChI key: MXOOUCRHWJYCAL-UHFFFAOYSA-N

Description

General description

A broad-spectrum cell-permeable and irreversible caspase inhibitor.

A cell-permeable, irreversible, broad-spectrum caspase inhibitor.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
broad spectrum caspase

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 4 months at 4°C or for up to 1 year at -20°C.

Analysis Note

single spot by TLC

Other Notes

Boc-Asp(OMe)-CH₂F*

Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
D’Mello, S.R., et al. 1998. J. Neurochem. 70, 1809.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable