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20-107

Peroxynitrite

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About This Item

UNSPSC Code:
41116012
NACRES:
NA.41
eCl@ss:
32160405
Form:
liquid
Pricing and availability is not currently available.
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form

liquid

Quality Level

100

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

shipped in

dry ice

General description

Peroxynitrite (ONOO−) is a powerful oxidant formed by the collision of nitric oxide and superoxide.[1]

Application

Peroxynitrite has been used to induce pericyte contraction in mouse brains.[1] It has also been used for the preparation of positive control nitrated protein standards in immunohistochemical studies.[2]

Biochem/physiol Actions

Peroxynitrite (ONOO−) exhibits bactericidal activity.[3] It promotes cell death and contributes to the signal-transduction process, mitochondrial function, and apoptotic pathway. The formation of peroxynitrite has been associated with the development of various diseases including vascular diseases, ischemia-reperfusion injury, circulatory shock, inflammation, pain, and neurodegeneration.[1]

Physical form

0.3M NaOH

Analysis Note

Routinely evaluated by treating non-stimulated A431 cells.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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This Item
SCT035N0409C221
Peroxynitrite

Sigma-Aldrich

20-107

Peroxynitrite

BioTracker 515 Green ONOO- Dye Live cell imaging dye for peroxynitrite (ONOO-) used to detect reactive oxygen species (ROS) generated from the interaction of nitric oxide (NO) and superoxide (O).

Sigma-Aldrich

SCT035

BioTracker 515 Green ONOO- Dye

Anti-Nitrotyrosine antibody produced in rabbit affinity isolated antibody, buffered aqueous solution

Sigma-Aldrich

N0409

Anti-Nitrotyrosine antibody produced in rabbit

Carboxy-PTIO potassium salt

Sigma-Aldrich

C221

Carboxy-PTIO potassium salt

Quality Level

100

Quality Level

-

Quality Level

200

Quality Level

100

form

liquid

form

-

form

buffered aqueous solution

form

powder

technique(s)

western blot: suitable

technique(s)

cell based assay: suitable

technique(s)

immunohistochemistry (frozen sections): 1:1000 using methacarn-fixed, frozen sections of human Alzheimer′s Disease brain, indirect ELISA: 1:1,000 using nitrated-BSA, indirect immunofluorescence: 1:1,000 using A549 cells metabolically labeled with 3-nitrotyrosine, microarray: suitable, western blot: 1:1,000 using nitrated-BSA

technique(s)

-

manufacturer/tradename

Upstate®

manufacturer/tradename

-

manufacturer/tradename

-

manufacturer/tradename

-

shipped in

dry ice

shipped in

ambient

shipped in

dry ice

shipped in

-

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pictograms

Corrosion
GHS05

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Storage Class

12 - Non Combustible Liquids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Csaba Szabó et al.
Nature reviews. Drug discovery, 6(8), 662-680 (2007-08-02)
Peroxynitrite--the product of the diffusion-controlled reaction of nitric oxide with superoxide radical--is a short-lived oxidant species that is a potent inducer of cell death. Conditions in which the reaction products of peroxynitrite have been detected and in which pharmacological inhibition
Hongjun Jin et al.
Current protocols in toxicology, Chapter 17, Unit 17-Unit 17 (2012-04-19)
Reactive nitrogen species (RNS) and reactive oxygen species (ROS) are derived as a result of inflammation and oxidative stress and can result in protein modifications. As such, these protein modifications are used as biomarkers for inflammation and oxidative stress. In
Oxidative chemistry of peroxynitrite.
Beckman, J S, et al.
Test, 233, 229-240 (1994)
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Global Trade Item Number

SKUGTIN
20-10704053252671265
Z114014-144EA04061832325828
Z114014-12EA04061832325811

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