According to the supplier, the HPLC C18 Column has dimensions of 4.6 mm x 25 cm and uses a solvent mixture of Acetonitrile, Methanol, and Water in a ratio of 28:28:44, with a flow rate of 2 mL/min and UV254 Detection. The compound is reported to be soluble in DMSO at 200 mg/mL, but very poorly soluble in ethanol and water. The maximum solubility in plain water is estimated to be about 10-50 um, and the solubility may be affected by the presence of buffers, serum, or other additives.
19-147
U0126
solid, suitable for kinase activity assay
Synonym(s):
Kinase inhibitor, MEK inhibitor
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.41
eCl@ss:
32160405
Pricing and availability is not currently available.
Product Name
U0126, U0126 is a elective inhibitor of MEK-1 and MEK-2; weak inhibitor of PKC, Raf, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, Abl, Cdk2 and Cdk4.
Quality Segment
form
solid
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable (kinase)
NCBI accession no.
shipped in
wet ice
Gene Information
human ... MAP2K1(5604)
Biochem/physiol Actions
Inhibitor Type: Kinase
Protein Target: MAPKK 1
Physical form
C18H16N6S2
Preparation Note
2 years at -20°C
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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This Item | |||
|---|---|---|---|
| Gene Information human ... MAP2K1(5604) | Gene Information - | Gene Information - | Gene Information - |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| form solid | form - | form solid | form powder |
| shipped in wet ice | shipped in - | shipped in - | shipped in - |
| technique(s) activity assay: suitable (kinase) | technique(s) activity assay: suitable (kinase) | technique(s) - | technique(s) - |
| UniProt accession no. | UniProt accession no. - | UniProt accession no. - | UniProt accession no. - |
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Could you please provide the column used for the purity by HPLC specification?
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