This product is intended for research and development purposes only and should not be used in drug or clinical applications.
D9628
3,4-ジヒドロキシ-L-フェニルアラニン
3,4-Dihydroxy-L-phenylalanine
≥98% (TLC)
別名:
3-(3,4-ジヒドロキシフェニル)-L-アラニン, L-3-ヒドロキシチロシン, L-DOPA, レボドパ
ログイン組織・契約価格を表示する
すべての画像(5)
About This Item
化学式:
(HO)2C6H3CH2CH(NH2)CO2H
CAS番号:
分子量:
197.19
Beilstein:
2215169
EC Number:
MDL番号:
UNSPSCコード:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.32
現在、価格および在庫状況を閲覧できません。
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製品名
3,4-ジヒドロキシ-L-フェニルアラニン, ≥98% (TLC)
品質水準
アッセイ
≥98% (TLC)
フォーム
powder
色
white to off-white
mp
276-278 °C (lit.)
アプリケーション
peptide synthesis
保管温度
room temp
SMILES記法
N[C@@H](Cc1ccc(O)c(O)c1)C(O)=O
InChI
1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
InChI Key
WTDRDQBEARUVNC-LURJTMIESA-N
遺伝子情報
human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816)
mouse ... DRD1(13488) , DRD2(13489) , DRD3(13490) , DRD4(13491) , DRD5(13492)
rat ... DRD1(24316) , DRD2(24318) , DRD3(29238) , DRD4(25432) , DRD5(25195)
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アプリケーション
生物化学的／生理学的作用
3,4-ジヒドロキシ-L-フェニルアラニンまたはL-DOPAは、血液脳関門を通過するドーパミンの直接的な前駆体の天然異性体です。これは、パーキンソン病[3]の治療に使用され、チロシンヒドロキシラーゼの産物です。
シグナルワード
Warning
危険有害性情報
危険有害性の分類
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
ターゲットの組織
Respiratory system
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
dust mask type N95 (US), Eyeshields, Gloves
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
D9628-500MG:
D9628-1G:
D9628-25G:
D9628-BULK:
D9628-5G:
D9628-250MG:
D9628-100G:
D9628-500G:
D9628-VAR:
最新バージョンのいずれかを選択してください：
試験成績書（COA）
Lot/Batch Number
この製品を見ている人はこちらもチェック
Effects of small-molecule amyloid modulators on a Drosophila model of Parkinson?s disease
Malgorzata Pokrzywa
PLoS ONE (2017)
Primary culture of human face skin melanocytes for the study of hyperpigmentation
Cytotechnology, 66(6) (2014)
Alan J. Sinclair, John E. Morley, Bruno Vellas
Pathy's Principles and Practice of Geriatric Medicine (2012)
Sebastiaan P van Kessel et al.
Nature communications, 10(1), 310-310 (2019-01-20)
Human gut microbiota senses its environment and responds by releasing metabolites, some of which are key regulators of human health and disease. In this study, we characterize gut-associated bacteria in their ability to decarboxylate levodopa to dopamine via tyrosine decarboxylases.
Nicolas Morin et al.
Experimental neurology, 256, 105-116 (2013-01-31)
The treatment of motor symptoms of Parkinson disease (PD) with the dopamine (DA) precursor, l-3,4-dihydroxyphenylalanine (l-DOPA) introduced 50years ago still remains a very effective medication. However, involuntary movements termed l-DOPA-induced dyskinesias (LID) appear in the vast majority of PD patients
Chromatograms
application for HPLCapplication for HPLC-
Esta levodopa pode ser utilizada em processos de nanoencapsulamento para tratamento da doença de Parkinson?
1 回答-
役に立ちましたか？
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How can I determine the shelf life / expiration / retest date of this product?
1 回答-
If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf役に立ちましたか？
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 回答-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
役に立ちましたか？
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Hello I want to perform some enzyme activity assays with tyrosinase from mushroom , is this reagent suitable as a substrate to perform the assay by spectrophotometry? Thank you very much!
1 回答-
Yes, this product is used as a substrate in enzymatic analysis of product T3824, Tyrosinase from mushroom. This assay is performed to determine the polyphenol oxidase activity of the enzyme. The unit definition of Tyrosinase product is as follows:
One unit will cause a decrease in A265 of 0.001 per minute at pH 6.5 at 25 deg C. In a 3 mL reaction mixture containing L-Beta-3,4-dihydroxyphenyl-alanine (L-DOPA)Please see the link below to review a sample or lot-specific Certificate of Analysis for the T3824 Tyrosinase product to review this and additional substrates used to establish activity:
https://www.sigmaaldrich.com/product/sigma/t3824#product-documentation役に立ちましたか？
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I want to know the solvent, storage method, and storage period.
1 回答-
As mentioned in the product Data Sheet, L-DOPA is slightly soluble in water (approximately 3.3 mg/ml) and in acidic and basic solutions. It is practically insoluble in ethanol. The stability of the product in solution has not been determined. See the statement below for further information. The recommended storage temperature is room temperature. Please view the datasheet for more information:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/315/570/d9628pis.pdfSee the link below to a publication regarding the solution stability of L-Dopa that may be helpful:
https://pubmed.ncbi.nlm.nih.gov/8771063/This product is not assigned an expiration date or recommended retest date. Products with no expiration date or recommended retest date should be routinely inspected by customers to ensure they perform as expected. These products are also subject to a one-year warranty from the date of shipment. For more information, you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/quality-services.
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