Y0002055

Fingolimod hydrochloride

European Pharmacopoeia (EP) Reference Standard

• Szinonimák: FTY720, 2-Amino-2-[2-(4-octyl-phenyl)-ethyl]-propane-1,3-diol hydrochloride, Fingolimod hydrochloride
• Tapasztalati képlet (Hill-képlet): C₁₉H₃₃NO₂ · HCl
• CAS-szám: 162359-56-0
• Molekulatömeg: 343.93
• UNSPSC kód: 41116107
• NACRES: NA.24

Tulajdonságok

• biológiai forrás: synthetic
• grade: pharmaceutical primary standard
• Ügynökség: EP
• API-család: fingolimod
• Forma: powder
• kiszerelés: pkg of 110 mg
• gyártó/kereskedő neve: EDQM
• tárolási körülmény: protect from light
• oldhatóság: water: 100-1000 g/L
• alkalmazás(ok): pharmaceutical
• Formátum: neat
• kiszállítva: ambient
• tárolási hőmérséklet: 2-8°C
• SMILES string: Cl.NC(CO)(CO)CCc1ccc(cc1)CCCCCCCC
• InChI: 1S/C19H33NO2.ClH/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22;/h9-12,21-22H,2-8,13-16,20H2,1H3;1H
• Nemzetközi kémiai azonosító kulcs: SWZTYAVBMYWFGS-UHFFFAOYSA-N

Leírás

Általános leírás

Fingolimod Hydrochloride (fingolimod HCl), an S1P-receptor modulator, belongs to the class of synthetic glucocorticoid steroid drugs.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Alkalmazás

This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia.

Biokémiai/fiziológiai hatások

FTY720 is an immunomodulating drug and sphingosine 1-phosphate (S1P) receptor modulator. Phosphorylation of FTY270 by sphingosine kinase causes S1P1R internalization, which sequesters lymphocytes in lymph nodes, preventing them from taking part in an autoimmune response. Clinically, it has been approved for the treatment of multiple sclerosis (MS). It has also been shown to block and reverse paclitaxel-induced chemotherapy induced peripheral neuropathy (CIPN) through S1PR inhibition as well as inhibit the activity of histone deacetylases in the hippocampus of mouse brains, thereby modulating memory.

Kiszerelés

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Egyéb megjegyzések

Sales restrictions may apply.

Biztonsági adatok

• Piktogramok: GHS08
• Figyelmeztetés: Warning
• Figyelmeztető mondatok: H373
• Óvintézkedésre vonatkozó mondatok: P260 - P314 - P501
• Veszélyességi osztályok: STOT RE 2
• Célzott szervek: Immune system
• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable