L9043

Lysostaphin from Staphylococcus simulans

recombinant, expressed in E. coli, lyophilized powder

• Szinonimák: Glycyl-glycine Endopeptidase
• CAS-szám: 9011-93-2
• Enzyme Commission szám: 3.4.24.75 (BRENDA, IUBMB)
• MDL-szám: MFCD00131556
• UNSPSC kód: 12352204
• NACRES: NA.54

Tulajdonságok

• biológiai forrás: bacterial
• Minőségi szint: 200
• rekombináns: expressed in E. coli
• Teszt: ≥90% (HPLC)
• form: lyophilized powder
• specifikus aktivitás: ≥3000 unit/mg solid
• technika/technikák: molecular cloning: suitable
• alkalmasság: suitable for sequence analysis test
• alkalmazás(ok): life science and biopharma
• kiszállítva: dry ice
• tárolási hőmérséklet: −20°C

Leírás

Általános leírás

Lysostaphin, a zinc metalloenzyme, is mainly secreted as a proenzyme. It acts as an anti-staphylococcal agent and is highly stable at pH 4 and 5°C.

Alkalmazás

Lysostaphin from Staphylococcus simulans has been used in a study to assess molecular cloning, sequencing, and expression of lytM, a unique autolytic gene of Staphylococcus aureus. It has also been used in a study to investigate the sequence analysis of a Staphylococcus aureus gene encoding a peptidoglycan hydrolase activity.

Biokémiai/fiziológiai hatások

A protein complex with highly specific lytic activity against Staphylococcus species, including Staphylococcus aureus.

Lysostaphin possesses a lytic action against Staphylococcus aureus, which is used to treat antibiotic-resistant staphylococcal infections. It has the properties of enzymes, such as glycylglycine endopeptidase, endo-β-N-acetyl glucosamidase and N-acetyl muramyl-L-alanine amidase. Lysostaphin is also used as a preservative in food industry and in clinical labs for rapid screening.

The antimicrobial activity of lysostaphin, a metalloendopeptidase expressed by Staphylococcus simulans, is enhanced by binding to the C′ terminus of the membrane-associated Trap protein of Staphylococcus aureus.

Biztonsági adatok

• Piktogramok: GHS08
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H334
• Óvintézkedésre vonatkozó mondatok: P261 - P284 - P501
• Veszélyességi osztályok: Resp. Sens. 1
• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Gloves, type N95 (US)