L5399

Lipid A, diphosphoryl from Escherichia coli F583 (Rd mutant)

• Szinonimák: Diphosphoryl Lipid A from E.Coli.
• MDL-szám: MFCD00131510
• UNSPSC kód: 12352211
• PubChem Substance ID: 24896402
• NACRES: NA.25

Tulajdonságok

• biológiai forrás: Escherichia coli (F583 Rd mutant)
• Minőségi szint: 200
• Forma: lyophilized powder
• kiszállítva: ambient
• tárolási hőmérséklet: 2-8°C
• SMILES string: CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)C(OCC2OC(OP(O)(O)=O)C(NC(=O)CC(O)CCCCCCCCCCC)C(OC(=O)CC(O)CCCCCCCCCCC)C2O)OC(CO)C1OP(O)(O)=O
• InChI: 1S/C94H178N2O25P2/c1-7-13-19-25-31-37-38-44-50-56-62-68-84(103)115-78(66-60-54-48-42-35-29-23-17-11-5)72-86(105)119-92-88(96-82(101)71-77(65-59-53-47-41-34-28-22-16-10-4)114-83(102)67-61-55-49-43-36-30-24-18-12-6)93(116-79(73-97)90(92)120-122(107,108)109)113-74-80-89(106)91(118-85(104)70-76(99)64-58-52-46-40-33-27-21-15-9-3)87(94(117-80)121-123(110,111)112)95-81(100)69-75(98)63-57-51-45-39-32-26-20-14-8-2/h75-80,87-94,97-99,106H,7-74H2,1-6H3,(H,95,100)(H,96,101)(H2,107,108,109)(H2,110,111,112)
• Nemzetközi kémiai azonosító kulcs: GZQKNULLWNGMCW-UHFFFAOYSA-N

Leírás

Általános leírás

Lipid A is the fundamental structure of lipopolysaccharides (LPS), present in bacteria.

Alkalmazás

Lipid A, diphosphoryl from Escherichia coli F583 (Rd mutant) has been used:

• to study the effect of various lipid A molecules on lung pericyte proliferation in vitro
• to test on THP-1 and J774A.1 cells for neopterin and nitrite formation respectively
• as lipopolysaccharides (LPS) derivatives in binding experiments
• to stimulate the spleen cells and as a mitogen stimulation for toll like receptor 4 (TLR4)

Biokémiai/fiziológiai hatások

Lipid A is mainly essential for the robust immunostimulatory activities of lipopolysaccharides (LPS) in human. Lipid A is the hydrophobic domain of LPS helps in anchoring LPS to the plasma membrane of bacteria. It is immunologically active and an important constituent of LPS recognised by immune system.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Gloves, type N95 (US)