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Merck

L6895

Sigma-Aldrich

Lipid A, monophosphoryl from Salmonella enterica serotype minnesota Re 595 (Re mutant)

lyophilized powder, TLR ligand tested

Szinonimák:

Monophosphoryl Lipid A from Salmonella

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez


About This Item

MDL-szám:
UNSPSC kód:
12352211
NACRES:
NA.25

biológiai forrás

Salmonella enterica (serotype minnesota Re 595 Re mutant)

Minőségi szint

Forma

lyophilized powder

szennyeződések

<0.2% Ketodeoxyoctonate (KDO)

kiszállítva

ambient

tárolási hőmérséklet

2-8°C

Alkalmazás

Lipid A molecules compose the lipid membrane anchoring core components of endotoxins produced by Gram-negative bacteria. Lipid A molecules induce immune responses. Structually, lipid A molecules are composed of two glucosamine units with varied, species dependent, fatty acyl chain numbers and identity and degree of phosphorylation.
Lipid A, monophosphoryl from Salmonella enterica serotype minnesota Re 595 may be used in comparative assessment of the antigenicity of specific structures within different LPA molecules and analogues.

Biokémiai/fiziológiai hatások

Lipid A has immunostimulatory adjuvant activity including macrophage, T-cell, and B-cell activation. Research has shown Lipid A has greater Th1 than Th2 stimulation.
Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).

Tárolási osztály kódja

11 - Combustible Solids

WGK

WGK 3

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable

Egyéni védőeszköz

Eyeshields, Gloves, type N95 (US)


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Analitikai tanúsítványok (COA)

Lot/Batch Number

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Dokumentumtár megtekintése

Tarik A Khan et al.
Science advances, 2(3), e1501371-e1501371 (2016-03-22)
High-throughput antibody repertoire sequencing (Ig-seq) provides quantitative molecular information on humoral immunity. However, Ig-seq is compromised by biases and errors introduced during library preparation and sequencing. By using synthetic antibody spike-in genes, we determined that primer bias from multiplex polymerase
S Hutchison et al.
Veterinary immunology and immunopathology, 216, 109912-109912 (2019-08-26)
Melanoma in humans and canines is an aggressive and highly metastatic cancer. The mucosal forms in both species share genetic and histopathologic features, making dogs a valuable spontaneous disease animal model. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of
Melissa C Hanson et al.
Vaccine, 33(7), 861-868 (2015-01-07)
An HIV vaccine capable of inducing high and durable levels of broadly neutralizing antibodies has thus far proven elusive. A promising antigen is the membrane-proximal external region (MPER) from gp41, a segment of the viral envelope recognized by a number
Yanjun Zhang et al.
Antiviral research, 165, 11-22 (2019-03-02)
Respiratory syncytial virus (RSV) infection causes significant disease in the lower respiratory tract of young children, and there is currently no licensed vaccine to prevent RSV infection. The F glycoprotein is considered a major antigenic target for RSV vaccine development.
Tyler J Van De Voort et al.
Journal of immunotherapy (Hagerstown, Md. : 1997), 36(1), 29-40 (2012-12-06)
In this study, an agonistic anti-CD40 monoclonal antibody was combined with monophosphoryl lipid A (MPL), a nontoxic derivative of lipopolysaccharide and agonist of toll-like receptor-4, to assess the immunomodulatory and antitumor synergy between the 2 agents in mice. Anti-CD40 was

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