I8779
Insulin-like Growth Factor-I from mouse
≥98% (SDS-PAGE & HPLC), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Szinonimák:
IGF-I
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
Javasolt termékek
product name
Insulin-like Growth Factor-I from mouse, IGF-I, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
biológiai forrás
mouse
Minőségi szint
rekombináns
expressed in E. coli
Teszt
≥98% (SDS-PAGE and HPLC)
form
lyophilized powder
minőség
endotoxin tested
molekulatömeg
predicted mol wt ~7.6 kDa
kiszerelés
glass bottle of 50 μg (in glass insert)
technika/technikák
cell culture | mammalian: suitable
szennyeződések
<0.1 ng/mg (LAL test)
UniProt elérési szám
tárolási hőmérséklet
−20°C
Géninformáció
human ... IGF1(3479)
mouse ... Igf1(16000)
Általános leírás
Insulin-like growth factor I (IGF-I) belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules. IGF-I is also known as somatomedin. In the developing embryo IGF-I is expressed primarily by mesenchymal-derived cells.
Alkalmazás
Insulin-like Growth Factor-I from mouse has been used:
- for the preparation of growth factor cocktail
- as a media supplement for mouse embryonic fibroblasts culture
- as a media supplement to serve as a positive control to investigate
- the effects of Angelica sinensis on myotubes
Biokémiai/fiziológiai hatások
Insulin-like growth factor I (IGF-I) plays critical roles in cellular energy metabolism and in growth and development, especially prenatal growth.
IGF-I is secreted from the liver into circulation in a process regulated by pituitary growth hormone (GH) and so it mediates the growth-promoting activity of GH. After birth IGF-I expression in most extrahepatic tissues declines and hepatic expression of IGF-I becomes GH-regulated. Expression of IGF-I outside the liver is regulated differently, depending on the specific tissues. For example, gonadotropins and sex steroids regulate IGF-I expression within the reproductive system, while parathyroid hormone and sex steroids regulate IGF-I expression in bone. IGF-I is produced in several human tumors. IGF-I is mitogenic for a variety of cells including fibroblasts, osteoblasts, smooth muscle cells, fetal brain cells, neuroglial cells, and erythroid progenitor cells. IGF-I exerts its actions exclusively through the IGF-I receptor (IGF-IR). IGF-I induces endothelial cell migration and is involved in the regulation of angiogenesis.
IGF-I is secreted from the liver into circulation in a process regulated by pituitary growth hormone (GH) and so it mediates the growth-promoting activity of GH. After birth IGF-I expression in most extrahepatic tissues declines and hepatic expression of IGF-I becomes GH-regulated. Expression of IGF-I outside the liver is regulated differently, depending on the specific tissues. For example, gonadotropins and sex steroids regulate IGF-I expression within the reproductive system, while parathyroid hormone and sex steroids regulate IGF-I expression in bone. IGF-I is produced in several human tumors. IGF-I is mitogenic for a variety of cells including fibroblasts, osteoblasts, smooth muscle cells, fetal brain cells, neuroglial cells, and erythroid progenitor cells. IGF-I exerts its actions exclusively through the IGF-I receptor (IGF-IR). IGF-I induces endothelial cell migration and is involved in the regulation of angiogenesis.
Potent mitogenic growth factor that mediates the growth-promoting activities of growth hormone postnatally. Mouse and human IGF-I share 97% sequence identity.
Fizikai forma
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
Analízis megjegyzés
The biological activty is measured in a serum-free cell proliferation assay using the human breast carcinoma cell line, MCF-7.
kapcsolódó termék
Product No.
Leírás
Árazás
Tárolási osztály kódja
11 - Combustible Solids
WGK
WGK 3
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Egyéni védőeszköz
Eyeshields, Gloves, type N95 (US)
Analitikai tanúsítványok (COA)
Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.
Már rendelkezik ezzel a termékkel?
Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.
Az ügyfelek ezeket is megtekintették
Early tissue patterning recreated by mouse embryonic fibroblasts in a three-dimensional environment
Tissue Engineering: Part A, 15(1), 45-54 (2008)
Angelica Sinensis promotes myotube hypertrophy through the PI3K/Akt/mTOR pathway
Yeh TS, et al.
BMC Complementary and Alternative Medicine, 14(1), 144-144 (2014)
Simone Frisari et al.
International journal of molecular sciences, 23(3) (2022-02-16)
FOXG1 is an ancient transcription factor gene mastering telencephalic development. A number of distinct structural FOXG1 mutations lead to the "FOXG1 syndrome", a complex and heterogeneous neuropathological entity, for which no cure is presently available. Reconstruction of primary neurodevelopmental/physiological anomalies
Julie Chenal et al.
The European journal of neuroscience, 27(1), 53-65 (2007-12-21)
MCT2 is the main neuronal monocarboxylate transporter essential for facilitating lactate and ketone body utilization as energy substrates. Our study reveals that treatment of cultured cortical neurons with insulin and IGF-1 led to a striking enhancement of MCT2 immunoreactivity in
Soumya Pati et al.
BioMed research international, 2014, 503162-503162 (2014-09-26)
The striatum is considered to be the central processing unit of the basal ganglia in locomotor activity and cognitive function of the brain. IGF-1 could act as a control switch for the long-term proliferation and survival of EGF+bFGF-responsive cultured embryonic
Cikkek
Insulin-like Growth Factors (IGF)
Tudóscsoportunk valamennyi kutatási területen rendelkezik tapasztalattal, beleértve az élettudományt, az anyagtudományt, a kémiai szintézist, a kromatográfiát, az analitikát és még sok más területet.
Lépjen kapcsolatba a szaktanácsadással