H7666

IL-12 human

HumanKine^®, recombinant, Xeno-free, >95% (SDS-PAGE), suitable for cell culture

• Szinonimák: IL-12
• MDL-szám: MFCD00212975
• UNSPSC kód: 12352202
• NACRES: NA.77

Tulajdonságok

• product name: Interleukin-12 human, HumanKine^®, recombinant, expressed in HEK 293 cells, suitable for cell culture, endotoxin, tested
• biológiai forrás: human
• Minőségi szint: 200
• rekombináns: expressed in HEK 293 cells
• Teszt: ≥95% (SDS-PAGE)
• form: lyophilized
• hatékonyság: ≤2 ng/mL EC₅₀
• molekulatömeg: dimer 57 kDa (glycosylated)
• kiszerelés: pkg of 10 μg
• technika/technikák: cell culture | mammalian: suitable
• szennyeződések: endotoxin, tested
• tárolási hőmérséklet: −20°C

Leírás

Alkalmazás

Interleukin-12 (IL-12) human has been used to study IL-12 mediated enhancement of IL-12Rβ2 (IL-12 receptor) expression.

Biokémiai/fiziológiai hatások

Interleukin-12 (IL-12) was identified as a factor secreted by human Epstein-Barr (EBV)-transformed B cell lines. IL-12, or Natural Killer Cell Stimulatory Factor (NKSF), is a 75 kDa disulfide-linked heterodimer of a 35 kDa subunit and 40 kDa subunit. IL-12 is produced predominantly by monocytes and NK cells and induces T cells and NK cells to produce IFN-γ. Human IL-12 is not active on mouse cells, but murine IL-12 is active on both murine and human lymphocytes. The biological activity of recombinant human IL-12 was measured by its ability to stimulate the proliferation of PHA-activated human T lymphoblasts. IL-12 has anti-angiogenic properties.

Fizikai forma

lyophilized from a 0.2 μm filtered solution of PBS

Analízis megjegyzés

The specific activity was determined by the dose-dependent release of IFN-γ from the human NK92 cell line in presence of 20 ng/mL rIL-2.

Jogi információk

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

Biztonsági adatok

• Tárolási osztály kódja: 12 - Non Combustible Liquids
• WGK: WGK 1
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable