G8415

L-Glutamic acid

98.5-100.5%, suitable for cell culture, non-animal source, meets EP testing specifications

• Szinonimák: (S)-2-Aminopentanedioic acid, Glu
• Lineáris képlet: HO₂CCH₂CH₂CH(NH₂)CO₂H
• CAS-szám: 56-86-0
• Molekulatömeg: 147.13
• Beilstein: 1723801
• EC-szám: 200-293-7
• MDL-szám: MFCD00002634
• UNSPSC kód: 12352209
• eCl@ss: 32160406
• PubChem Substance ID: 24895340
• NACRES: NA.26

Tulajdonságok

• Terméknév: L-Glutamic acid, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%
• biológiai forrás: non-animal source
• Minőségi szint: 300
• Ügynökség: meets EP testing specifications
• Teszt: 98.5-100.5%
• Forma: powder
• technika/technikák: cell culture | mammalian: suitable
• szennyeződések: endotoxin, tested
• szín: white
• mp: 205 °C (dec.) (lit.)
• oldhatóság: 1 M HCl: 100 mg/mL
• sűrűség: 1.54 g/cm³ at 20 °C
• anion nyomok: chloride (Cl^-): ≤200 ppm; sulfate (SO₄^2-): ≤200 ppm
• kation nyomok: As: ≤1 ppm, passes test; Fe: ≤10 ppm, passes test; NH₄⁺: ≤200 ppm, passes test
• alkalmazás(ok): pharmaceutical (small molecule)
• SMILES string: N[C@@H](CCC(O)=O)C(O)=O
• InChI: 1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
• Nemzetközi kémiai azonosító kulcs: WHUUTDBJXJRKMK-VKHMYHEASA-N
• Géninformáció: human ... CCR2(1231) , GRIA1(2890) , GRIA2(2891) , GRIA4(2893) , GRIK1(2897) , GRIK2(2898) , GRIK3(2899) , GRIK5(2901) , GRIN2B(2904) , GRM2(2912) , SLC1A1(6505) , SLC1A2(6506) ; rat ... Gria1(50592) , Grik1(29559) , Grik2(54257) , Grik4(24406) , Grin2a(24409) , Grm1(24414) , Grm2(24415) , Grm3(24416) , Grm4(24417) , Grm5(24418) , Grm6(24419) , Grm7(81672) , Slc1a2(29482)

Leírás

Alkalmazás

L-Glutamic acid has been used as a supplement in for cell culture media to culture hippocampal neurons and hT-PA (human tissue plasminogen activation) producing cell line.[1][2][3]

Biokémiai/fiziológiai hatások

Glutamic acid, or glutamate, the salt form of glutamic acid, functions as a neurotransmitter and also serves as a precursor to other neurotransmitters such as γ-aminobutyric acid.[4] Glutamic acid also plays a key role in many metabolic pathways, that controls growth, reproduction, maintenance and immunity.[5] It is converted to α-ketoglutarate, a key component of the TCA (tricarboxylic acid) cycle, and a precursor for the biosynthesis of nucleic acids and certain amino acids.[5][6] In cells, glutamine is converted to glutamate by the enzyme glutaminase.[6] Glutamine serves as a source of energy for rapidly dividing cells comprising lymphocytes, enterocytes, macrophages and tumors. Glutamine mediates protein turnover via cellular mTOR (mammalian target of rapamycin) signaling. It is also known to be associated with the inhibition of apoptosis.[5]

An excitatory amino acid neurotransmitter that is an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 1
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Gloves, type N95 (US)