D3179

2-Deoxy-D-glucose

≥98% (GC), BioXtra

• Szinonimák: 2-Deoxy-D-arabinohexose
• Tapasztalati képlet (Hill-képlet): C₆H₁₂O₅
• CAS-szám: 154-17-6
• Molekulatömeg: 164.16
• Beilstein: 1723331
• EC-szám: 205-823-0
• MDL-szám: MFCD00151328
• UNSPSC kód: 12352201
• PubChem Substance ID: 24893732
• NACRES: NA.25

Tulajdonságok

• biológiai forrás: synthetic (organic)
• Minőségi szint: 200
• termékcsalád: BioXtra
• Teszt: ≥98% (GC)
• form: powder
• technika/technikák: gas chromatography (GC): suitable
• szennyeződések: ≤0.001% Phosphorus (P); <0.1% Insoluble matter
• izzítási maradék: <0.1%
• szín: white
• mp: 146-147 °C (lit.)
• oldhatóság: H₂O: 1 M at 20 °C, clear, colorless
• anion nyomok: chloride (Cl^-): ≤0.05%; sulfate (SO₄^2-): ≤0.05%
• kation nyomok: Al: ≤0.0005%; Ca: ≤0.003%; Cu: ≤0.0005%; Fe: ≤0.0005%; K: ≤0.005%; Mg: ≤0.001%; NH₄⁺: ≤0.05%; Na: ≤0.005%; Pb: ≤0.001%; Zn: ≤0.0005%
• tárolási hőmérséklet: 2-8°C
• SMILES string: OC[C@@H](O)[C@@H](O)[C@H](O)CC=O
• InChI: 1S/C6H12O5/c7-2-1-4(9)6(11)5(10)3-8/h2,4-6,8-11H,1,3H2/t4-,5-,6+/m1/s1
• Nemzetközi kémiai azonosító kulcs: VRYALKFFQXWPIH-PBXRRBTRSA-N

Leírás

Alkalmazás

2-Deoxy-D-glucose was used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress. It was used in glucoprivic feeding research to invoke and study the processes of counter-regulatory response (CRR).

Biokémiai/fiziológiai hatások

2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its action on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increases ROS production, and activate AMPK.

2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.

Egyéb megjegyzések

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Gloves, type N95 (US)