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C3788

Sigma-Aldrich

Chondroitin sulfate B sodium salt

from Porcine intestinal mucosa, ≥90%, lyophilized powder

Szinonimák:

β-Heparin, Dermatan sulfate sodium salt

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
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About This Item

CAS-szám:
54328-33-5
MDL-szám:
MFCD00151683
UNSPSC kód:
12352201
NACRES:
NA.25

biológiai forrás

Porcine intestinal mucosa

Minőségi szint

200

Teszt

≥90%

Forma

lyophilized powder

szennyeződések

≤20% water (Karl Fischer)

szín

white

oldhatóság

H2O: 5 mg/mL, clear, colorless

kation nyomok

Na: 7.0-11.5%

tárolási hőmérséklet

2-8°C

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Általános leírás

Chondroitin, a glucosaminoglycan (GAG), is a polysaccharide chain of alternating units of N-acetylgalactosamine (GalNAc) and glucuronic acid (GlcA) that can be sulfated on the either or both GalNAc and GlcA units. Chondroitin and its sulfates are frequently attached to proteins to form proteoglycans. Chondroitin sulfate B (Dermatam sulfate) is a component of proteoglycans such as decorin, biglycan and versican. Chondroitin sulfate B is used to study β peptide (1-42) cytotoxicity.

Alkalmazás

Chondroitin sulfate B may be used to study its roles as a biomolecule receptor, mediator of cell signaling and cell binding molecule. It may be used to compare its properties to those of chondroitin sulfate A and chondroitin sulfate C. Chondroitin sulfate B is used to study β peptide(1-42) cytotoxicity.

Biokémiai/fiziológiai hatások

As a large, negatively charged, hydrophilic molecule that is too inflexible to fold into a compact globular structure, chondroitin sulfate molecules form porous hydrated gels, providing mechanical support to tissue and allowing rapid diffusion of water-soluble molecules and migration of cells.

Komponensek

Chondroitin Sulfate B is an acidic mucopolysaccharide found in cartilage, skin, cornea, and umbilical cord. It is composed of alternating N-acetylgalactosamine, L-iduronic acid, and sulfate residues in equimolar quantities where carbon 4 of the N-acetylgalactosamines is sulfated.

Vigyázat

Store this product at 2-8°C.

Elkészítési megjegyzés

This product is soluble in water at 100 mg/mL.

Egyéb megjegyzések

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Tárolási osztály kódja

11 - Combustible Solids

WGK

WGK 3

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable

Egyéni védőeszköz

Eyeshields, Gloves, type N95 (US)

Válasszon a legfrissebb verziók közül:

Analitikai tanúsítványok (COA)

Lot/Batch Number
0000417795
0000417795
0000401488
0000385498
0000365731

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Dokumentumtár megtekintése

X Fernàndez-Busquets et al.
Current Alzheimer research, 7(5), 428-438 (2010-01-02)
One mechanism leading to neurodegeneration during Alzheimer's disease (AD) is amyloid beta peptide (Abeta)-induced neurotoxicity. Among the factors proposed to potentiate Abeta toxicity is its covalent modification through carbohydrate-derived advanced glycation endproducts (AGEs). Other experimental evidence, though, indicates that certain
Sylvia Gruber et al.
International journal of molecular sciences, 19(6) (2018-06-09)
Oral mucositis is the most frequently occurring early side effect of head-and-neck cancer radiotherapy. Systemic dermatan sulfate (DS) treatment revealed a significant radioprotective potential in a preclinical model of oral mucositis. This study was initiated to elucidate the mechanistic effects
Rebecca Morgan et al.
The Journal of rheumatology, 31(8), 1497-1505 (2004-08-04)
Pristane induced arthritis (PIA) is a seropositive experimental murine model that closely resembles rheumatoid arthritis (RA). Immune reactivity to a broad spectrum of autoantigens has been recognized in this disease model. We investigated the specificity of the autoimmune response in
Nilsu Cini et al.
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 196(1), 85-94 (2019-11-11)
During head and neck cancer radiotherapy, oral mucositis is the most frequent early side effect. Systemic dermatan sulfate (DS) administration has been shown to significantly decrease oral mucosal radiation reactions during daily fractionated irradiation (IR) in an established mouse model.
Cheng Zhang et al.
Connective tissue research, 61(5), 475-484 (2019-05-29)
Recent data suggest that there is a lack of turnover in the core of human tendon, but it remains unknown whether there are regional differences between core and periphery of the cross section. The purpose of this project was to
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Cikkek

Glycosaminoglycans and Proteoglycans

Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.

Glycosaminoglycan Sulfation and Signaling

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

Tudóscsoportunk valamennyi kutatási területen rendelkezik tapasztalattal, beleértve az élettudományt, az anyagtudományt, a kémiai szintézist, a kromatográfiát, az analitikát és még sok más területet.

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