H7640

Heparan sulfate sodium salt from bovine kidney

powder, extracellular matrix component

• Szinonimák: Heparitin sulfate sodium salt
• CAS-szám: 57459-72-0
• MDL-szám: MFCD00131294
• UNSPSC kód: 12352200
• NACRES: NA.77

Tulajdonságok

• Terméknév: Heparan sulfate sodium salt from bovine kidney,
• Minőségi szint: 200
• tárolási hőmérséklet: 2-8°C

Leírás

Alkalmazás

Heparan sulfate sodium salt from bovine kidney has been used:

• to investigate its effect on proliferation of B cells
• to monitor its role on eye development in E5 embryonic cells
• to study its binding with exosome fibronectin in human trabecular meshwork cells using dot blot

Biokémiai/fiziológiai hatások

Heparan sulphate (HS), a ubiquitous glycosaminoglycan, is a polymer of D-glucuronic acid or L-iduronic acid and D-glucosamine (GlcA) sugars. It is synthesized in the cis-Golgi as heparan. In Golgi, final heparan sulphate is synthesized in by the action of enzymes N- and O-HS-sulphotransferases and HS epimerase. The mature HS has 50 to 200 disaccharide units. It is part of the extracellular matrix (ECM) and plays a key role in the oncogenic pathway. Deregulation of heparin sulfate metabolism is implicated in cancer progression. HS is associated with the onset of infectious diseases and inflammatory conditions. HS interaction with Aβ fibrils contributes to the pathophysiology of Alzheimer′s disease.Heparan sulphate is a constituent of membrane-associated proteoglycans suggested to contribute to cell-cell adhesion.

Constituent of membrane-associated proteoglycans suggested to contribute to cell-cell adhesion

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Gloves, type N95 (US)