B102

Bupropion hydrochloride

≥98% (HPLC), solid, dopamine and norepinephrine transporter inhibitor

• Szinonimák: (±)-1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride
• Tapasztalati képlet (Hill-képlet): C₁₃H₁₈ClNO · HCl
• CAS-szám: 31677-93-7
• Molekulatömeg: 276.20
• EC-szám: 250-759-9
• MDL-szám: MFCD00055209
• UNSPSC kód: 12352200
• PubChem Substance ID: 24277884
• NACRES: NA.77

Tulajdonságok

• Terméknév: Bupropion hydrochloride, ≥98% (HPLC), solid
• Minőségi szint: 100
• Teszt: ≥98% (HPLC)
• Forma: solid
• szín: white
• oldhatóság: H₂O: 15 mg/mL, clear
• kezdeményező: GlaxoSmithKline
• SMILES string: Cl[H].CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1
• InChI: 1S/C13H18ClNO.ClH/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10;/h5-9,15H,1-4H3;1H
• Nemzetközi kémiai azonosító kulcs: HEYVINCGKDONRU-UHFFFAOYSA-N
• Géninformáció: human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816) , SLC6A2(6530) , SLC6A3(6531)

Leírás

Általános leírás

Bupropion is structurally linked to the phenylethylamine family. It is a monocyclic aminoketone (chloropropiophenone).

Alkalmazás

Bupropion hydrochloride has been used as an anti-depressant and injected into mice intraperitoneally for forced swim test. It has also been used to study its effects on depression, anxiety and smoking cessation.

Biokémiai/fiziológiai hatások

Bupropion possesses antidepressant and anxiolytic properties. It serves as a good auxiliary for people who makes an effort to give up smoking. It may also be used in the treatment for attention-deficit hyperactivity disorder.

Inhibits the dopamine and norepinephrine transporters with K_is of 2.8 μM and 1.4 μM, respectively. Does not inhibit the serotonin transporter (K_i = 45 μM). Antidepressant.

Tulajdonságok és előnyök

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Biztonsági adatok

• Piktogramok: GHS07
• Figyelmeztetés: Warning
• Figyelmeztető mondatok: H302
• Veszélyességi osztályok: Acute Tox. 4 Oral
• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: dust mask type N95 (US), Eyeshields, Faceshields, Gloves