A9361

Artemether

≥98% (HPLC)

• Szinonimák: Dihydroartemisinin methyl ether, Dihydroqinghaosu methyl ether, SM-224
• Tapasztalati képlet (Hill-képlet): C₁₆H₂₆O₅
• CAS-szám: 71963-77-4
• Molekulatömeg: 298.37
• MDL-szám: MFCD00866205
• UNSPSC kód: 51101908
• PubChem Substance ID: 329771050
• NACRES: NA.77

Tulajdonságok

• Minőségi szint: 100
• Teszt: ≥98% (HPLC)
• Forma: powder
• optikai aktivitás: [α]/D +155 to +175°, c = 0.5 in methanol
• szín: off-white to light brown
• oldhatóság: DMSO: ≥20 mg/mL
• kezdeményező: Novartis
• tárolási hőmérséklet: room temp
• SMILES string: CO[C@H]1OC2O[C@@]3(C)CCC4[C@H](C)CCC([C@H]1C)[C@@]24OO3
• InChI: 1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1
• Nemzetközi kémiai azonosító kulcs: SXYIRMFQILZOAM-HVNFFKDJSA-N

Leírás

Általános leírás

Artemisinin (ART) is a natural compound present in Artemisia annua, a traditional Chinese plant.

Alkalmazás

Artemether has been used:

• as an anti-schistosomal compound to test it effect on the larval stages of S. mansoni
• to sensitize mouse embryonic fibroblasts (MEFs) and human osteosarcoma HT1080 cells to cysteine starvation (STV)-induced ferroptosis
• to stimulate islets and its effect on α to β transdifferentiation

Biokémiai/fiziológiai hatások

Artemether is a methyl ether derivative of artemisinin. It is used against multi-drug resistant strains of the malaria parasite, Plasmodium falciparum, and shows potential in treatment of schistosomiasis.

Artemisinin possesses a highly reactive endoperoxide bridge, which is core for its therapeutic potential. The endoperoxide bond reacts with iron in the erythrocytes with malarial parasite. This leads to the generation of reactive oxygen species (ROS) directly targeting the parasite. Artemisinin also regulates ferroptosis in tumor cells. The α cell transcription factor Arx expression is reduced by artemether. Prolonged exposure of primary islets also resulted in loss if identity in endocrine cell types and their functionality.

Tulajdonságok és előnyök

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Biztonsági adatok

• Piktogramok: GHS02,GHS07
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H242,H302
• Óvintézkedésre vonatkozó mondatok: P210 - P235 - P280 - P301 + P312 - P370 + P378 - P410
• Veszélyességi osztályok: Acute Tox. 4 Oral - Org. Perox. D
• Tárolási osztály kódja: 5.2 - Organic peroxides and self-reacting hazardous materials
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable