Ugrás a tartalomra
Merck
Összes fotó(2)

Fontos dokumentumok

A3731

Sigma-Aldrich

Artesunate

from Artemisia annua

Szinonimák:

Artesunic acid, dihydroartemisinine-12-alpha-succinate, succinyl dihydroartemisinin

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(2)

About This Item

Tapasztalati képlet (Hill-képlet):
C19H28O8
CAS-szám:
88495-63-0
Molekulatömeg:
384.42
UNSPSC kód:
51101914
NACRES:
NA.85

biológiai forrás

Artemisia annua

Minőségi szint

100

form

crystalline powder

szín

white to off-white

oldhatóság

acetone: 33.4 mg/mL

antibiotikus hatásspektrum

neoplastics
parasites

Hatásmechanizmus

protein synthesis | interferes

tárolási hőmérséklet

room temp

InChI

1S/C19H28O8/c1-10-4-5-13-11(2)16(23-15(22)7-6-14(20)21)24-17-19(13)12(10)8-9-18(3,25-17)26-27-19/h10-13,16-17H,4-9H2,1-3H3,(H,20,21)/t10-,11-,12+,13+,16+,17-,18?,19-/m1/s1

Nemzetközi kémiai azonosító kulcs

FIHJKUPKCHIPAT-JQXDXKTESA-N

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Általános leírás

Artesunate is a semisynthetic derivative of artemisinin used to treat malaria. It has also been shown to effective against other parasites such as liver flukes. Artesunate also demonstrates cytotoxic action against cancer cell lines of different tumor types.

Alkalmazás


  • Unrevealing the therapeutic potential of artesunate against emerging zoonotic Babesia microti infection in the murine model.: This study explores the efficacy of artesunate in treating Babesia microti infection, a zoonotic disease, in mice. The findings suggest that artesunate significantly reduces parasitemia, indicating its potential as a therapeutic agent for zoonotic infections (Fazilani et al., 2024).

  • Antitumour effects of artesunate via cell cycle checkpoint controls in human oesophageal squamous carcinoma cells.: The study investigates artesunate′s antitumor properties in oesophageal squamous carcinoma cells, highlighting its ability to regulate cell cycle checkpoints and inhibit cancer cell proliferation. These findings underscore artesunate′s potential in cancer therapy (Mao et al., 2024).

  • 3D printing of multi-unit gastro-retentive tablets for the pulsatile release of artesunate.: This study presents a novel approach to drug delivery using 3D-printed gastro-retentive tablets for the pulsatile release of artesunate. The technology promises improved bioavailability and therapeutic efficacy of artesunate for various medical conditions (Yan et al., 2024).


Biokémiai/fiziológiai hatások

Artesunate acts on the electron transport chain, generates local reactive oxygen species, and causes the depolarization of the mitochondrial membrane. It inhibits TNFα-induced production of proinflammatory cytokines via inhibition of NF-κB and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes.

Egyéb megjegyzések

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Piktogramok

Exclamation mark
GHS07

Figyelmeztetés

Warning

Figyelmeztető mondatok

H302 + H312 + H332

Veszélyességi osztályok

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Tárolási osztály kódja

13 - Non Combustible Solids

WGK

WGK 3

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable

Egyéni védőeszköz

dust mask type N95 (US), Eyeshields, Gloves

Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

Már rendelkezik ezzel a termékkel?

Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.

Dokumentumtár megtekintése

Shunyang Fan et al.
Annals of translational medicine, 8(20), 1291-1291 (2020-11-20)
The various anti-inflammatory, anti-apoptotic, and antioxidant effects of Artesunate (Art) have been explored in numerous studies. This study aimed to evaluate the function of Art on myocardial necrosis in apoptotic cardiomyocytes in vivo and in vitro. Sprague Dawley (SD) rats
H Xu et al.
Rheumatology (Oxford, England), 46(6), 920-926 (2007-02-23)
Recent studies indicate that the anti-malarial agent artemisinin and its derivatives may exert an anti-inflammatory effect. In this study, we explored the effect of artesunate, an artemisinin derivative, on tumour necrosis factor (TNF)-alpha-induced production of interleukins, IL-1beta, IL-6 and IL-8
Wei Li et al.
PLoS genetics, 1(3), e36-e36 (2005-09-20)
Artemisinins, derived from the wormwood herb Artemisia annua, are the most potent antimalarial drugs currently available. Despite extensive research, the exact mode of action of artemisinins has not been established. Here we use yeast, Saccharamyces cerevisiae, to probe the core
Weiyu Zhang et al.
Annals of translational medicine, 8(14), 858-858 (2020-08-15)
Prolactinoma is the most common hormone-secreting pituitary adenoma. Dopamine receptor agonists (DAs) are effective in reducing prolactin levels and tumor mass, but some prolactinoma patients are resistant to DAs. Treating patients with DA-resistant prolactinoma is challenging. In this study, we
Erica L L Warkus et al.
Toxicological sciences : an official journal of the Society of Toxicology, 157(1), 235-245 (2017-02-12)
Establishment of effective non-animal alternatives for developmental toxicity screening assays is desirable to ensure maternal and fetal health outcomes. Validation of such assays requires a comparison between the in vitro responses to chemical exposures and the in vivo impacts of
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