The reconstituted product is stable for 1 month at –20 °C and for at least 2 months at –70 °C. Product 528205, a prepared solution, also stored at -70°C, is assigned a retest schedule of every two years. See the link below to review this product page:
https://www.sigmaaldrich.com/US/en/product/mm/528205
Összes fotó(2)
Fontos dokumentumok
A8111
Plasminogen activator inhibitor 1 (PAI-1)
≥200,000 units/mg protein, lyophilized powder, ≥90% (SDS-PAGE)
Szinonimák:
PAIE, PLANH1, Plasminogen activator inhibitor, β-migrating endothelial cell-derived type, Serpin E1 PAI-1, Serpine 1
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Méret kiválasztása
25 μG
103 000,00 Ft
103 000,00 Ft
Az elérhetőséggel kapcsolatos kérdésekkel kérjük, forduljon Vevőszolgálatunkhoz.
Összes fotó(2)
Méret kiválasztása
Nézet módosítása
25 μG
103 000,00 Ft
About This Item
103 000,00 Ft
Az elérhetőséggel kapcsolatos kérdésekkel kérjük, forduljon Vevőszolgálatunkhoz.
Javasolt termékek
Terméknév
Plasminogen activator inhibitor 1 (PAI-1) human, recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
rekombináns
expressed in E. coli
Minőségi szint
Teszt
≥90% (SDS-PAGE)
Forma
lyophilized powder
specifikus aktivitás
≥200,000 units/mg protein
molekulatömeg
~43 kDa
oldhatóság
water: 0.1 mL, clear, colorless
UniProt elérési szám
kiszállítva
dry ice
tárolási hőmérséklet
−20°C
Géninformáció
human ... SERPINE1(5054)
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Általános leírás
Alkalmazás
Plasminogen activator inhibitor 1 (PAI-1) human has been used:
- as an inhibitor of pro-brain-derived neurotrophic factor (proBDNF) in radioimmunoprecipitation assay (RIPA) in peripheral blood and lymphocytes[3]
- to block plasmin activation in mice infected with C. albicans hyphae[4]
- to test its effect on neurite growth in neurons[5]
Biokémiai/fiziológiai hatások
Plasminogen Activator Inhibitor 1 (PAI-1) protein belongs to the Serpin superfamily of serine protease inhibitors. It is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), the activators of plasminogen and therefore inhibits the fibrinolysis process. PAI is involved in extracellular matrix remodeling and has been implicated in processes like angiogenesis, chemotaxis, ovulation, and embryogenesis. PAI-1 is present in increased levels in various disease states such as a number of cancer forms, obesity and the metabolic syndrome.
Plasminogen activator inhibitor 1 (PAI-1), a member of the Serpin superfamily of serine protease inhibitors, is involved in extracellular matrix remodeling and implicated in processes like angiogenesis, chemotaxis, ovulation, and embryogenesis.
Egység definíció
1 unit irreversibly inhibits (100% inhibition) 1 unit of tissue plasminogen activator (tPA) under physiological conditions (neutral pH and 37 ºC).
Fizikai forma
Supplied as a lyophilized powder from a solution containing 0.5 M sodium chloride, 20 mM sodium acetate, and 50 mg/mL trehalose.
Feloldás
Reconstitute to 0.25 mg/ml with ultrapure water. The reconstituted product contains 0.25 mgP/mL in 0.5 M sodium chloride, 20 mM sodium acetate, and 50 mg/mL trehalose.
Analízis megjegyzés
The product is the active human PAI-1 protein with a molecular weight of 43 kDa.
Tárolási osztály kódja
10 - Combustible liquids
WGK
WGK 1
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
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Analitikai tanúsítványok (COA)
Lot/Batch Number
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Az ügyfelek ezeket is megtekintették
Sadiya S Khan et al.
Science advances, 3(11), eaao1617-eaao1617 (2017-11-21)
Plasminogen activator inhibitor-1 (PAI-1) has been shown to be a key component of the senescence-related secretome and a direct mediator of cellular senescence. In murine models of accelerated aging, genetic deficiency and targeted inhibition of PAI-1 protect against aging-like pathology
Laura Yunes-Medina et al.
Molecular and cellular neurosciences, 86, 72-80 (2017-12-05)
The protein transglutaminase 2 (TG2) has been implicated as a modulator of neuronal viability. TG2's role in mediating cell survival processes has been suggested to involve its ability to alter transcriptional events. The goal of this study was to examine
William Santus et al.
Science immunology, 2(15) (2017-09-25)
Nuclear factor of activated T cells (NFAT) is activated in innate immune cells downstream of pattern recognition receptors, but little is known about NFAT's functions in innate immunity compared with adaptive immunity. We show that early activation of NFAT balances
Matteo Cesari et al.
Cardiovascular therapeutics, 28(5), e72-e91 (2010-07-16)
The close relationship existing between aging and thrombosis has growingly been studied in this last decade. The age-related development of a prothrombotic imbalance in the fibrinolysis homeostasis has been hypothesized as the basis of this increased cardiovascular and cerebrovascular risk.
Kirwin M Providence et al.
Archives of dermatological research, 300(6), 303-310 (2008-04-04)
Cutaneous tissue injury, both in vivo and in vitro, initiates activation of a "wound repair" transcriptional program. One such highly induced gene encodes plasminogen activator inhibitor type-1 (PAI-1, SERPINE1). PAI-1-GFP, expressed as a fusion protein under inducible control of +800
Cikkek
Lipid Induced Insulin Resistance
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Once it has been reconstituted, what is the recommended storage temperature? Will the reconstituted liquid be stable at 4 C for short-term storage (e.g. <24 hrs)?
1 answer-
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