Y0000698

Paclitaxel

European Pharmacopoeia (EP) Reference Standard

• Tapasztalati képlet (Hill-képlet): C₄₇H₅₁NO₁₄
• CAS-szám: 33069-62-4
• Molekulatömeg: 853.91
• Beilstein: 1420457
• MDL-szám: MFCD00869953
• UNSPSC kód: 41116107
• PubChem Substance ID: 329831102
• NACRES: NA.24

Tulajdonságok

• grade: pharmaceutical primary standard
• API-család: paclitaxel
• gyártó/kereskedő neve: EDQM
• mp: 213 °C (dec.) (lit.)
• alkalmazás(ok): pharmaceutical (small molecule)
• format: neat
• tárolási hőmérséklet: 2-8°C
• SMILES string: [H][C@@]12C[C@H](O)[C@@]3(C)C(=O)[C@H](OC(C)=O)C4=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)c5ccccc5)[C@]3([H])[C@@]1(CO2)OC(C)=O)C4(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)c6ccccc6)c7ccccc7
• InChI: 1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1
• Nemzetközi kémiai azonosító kulcs: RCINICONZNJXQF-MZXODVADSA-N
• Géninformáció: human ... TUBA1A(7846) , TUBA1B(10376) , TUBA1C(84790) , TUBA3C(7278) , TUBA3E(112714) , TUBA4A(7277) , TUBB(203068) , TUBB1(81027) , TUBB2A(7280) , TUBB2B(347733) , TUBB3(10381) , TUBB4A(10382) , TUBB4B(10383) , TUBB6(84617) , TUBB8(347688)

Leírás

Általános leírás

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Alkalmazás

Paclitaxel EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biokémiai/fiziológiai hatások

Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase. The microtubule damage induces apoptosis through a JNK-dependent pathway followed by a JNK-independent pathway, perhaps related to the activation of protein kinase A (PKA) or of Raf-1 kinase, resulting in phosphorylation of Bcl-2. A major metabolite via CYP2CB is 6α-hydroxypaclitaxel (6α-OHP).

Kiszerelés

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Vigyázat

Paclitaxel undergoes transesterification in methanol and hydrolyzes in aqueous solutions.

Egyéb megjegyzések

Sales restrictions may apply.

Biztonsági adatok

• Piktogramok: GHS08
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H341,H360FD,H372
• Óvintézkedésre vonatkozó mondatok: P202 - P260 - P264 - P280 - P308 + P313 - P405
• Veszélyességi osztályok: Muta. 2 - Repr. 1B - STOT RE 1
• Célzott szervek: Central nervous system,Bone marrow,Cardio-vascular system
• Tárolási osztály kódja: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable