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Y0000297

Mesalazine

European Pharmacopoeia (EP) Reference Standard

Szinonimák:

5-Aminosalicylic acid, 5-AS, 5-Amino-2-hydroxybenzoic acid, Mesalamine

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Összes fotó(1)

About This Item

Lineáris képlet:
H2NC6H3-2-(OH)CO2H
CAS-szám:
89-57-6
Molekulatömeg:
153.14
Beilstein:
2090421
MDL-szám:
MFCD00007877
UNSPSC kód:
41116107
PubChem Substance ID:
329830901
NACRES:
NA.24

grade

pharmaceutical primary standard

API-család

mesalamine, mesalazine

gyártó/kereskedő neve

EDQM

mp

275-280 °C (dec.) (lit.)

alkalmazás(ok)

pharmaceutical (small molecule)

Formátum

neat

tárolási hőmérséklet

2-8°C

SMILES string

Nc1ccc(O)c(c1)C(O)=O

InChI

1S/C7H7NO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,8H2,(H,10,11)

Nemzetközi kémiai azonosító kulcs

KBOPZPXVLCULAV-UHFFFAOYSA-N

Géninformáció

human ... ALOX5(240) , PPARG(5468) , PTGS1(5742) , PTGS2(5743)

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Általános leírás

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Alkalmazás

5-Aminosalicylic acid is a peroxidase substrate suitable for use in ELISA procedures. This substrate produces a soluble end product that is brown in color and can be read spectrophotometrically at 450 nm. The reaction may be stopped with 3 N NaOH and read at 550 nm.

Kiszerelés

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Egyéb megjegyzések

Sales restrictions may apply.

kapcsolódó termék

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Sulfanilic acid, United States Pharmacopeia (USP) Reference Standard

PHR1225

3-Aminophenol, Pharmaceutical Secondary Standard; Certified Reference Material

Y0001574

Mesalazine for system suitability, European Pharmacopoeia (EP) Reference Standard

Y0001563

Mesalazine impurity A, European Pharmacopoeia (EP) Reference Standard

Y0001569

Mesalazine impurity C, European Pharmacopoeia (EP) Reference Standard

PHR1419

Sulfanilic Acid, Pharmaceutical Secondary Standard; Certified Reference Material

1392705

Mesalamine, United States Pharmacopeia (USP) Reference Standard

1026004

m-Aminophenol, United States Pharmacopeia (USP) Reference Standard

PHR1739

Mesalazine Impurity C, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1741

2-Chloro-5-nitrobenzoic acid, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1742

2-Hydroxy-nitrobenzoic acid, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1745

4-Aminophenol hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

BP1075

Mesalazine, British Pharmacopoeia (BP) Reference Standard

PHR9052

3-Nitrosalicylic acid, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

PHR9053

2-Chloro-3-nitrobenzoic acid, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

PHR9056

2-Hydroxy-5-nitrobenzoic acid, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

PHR9138

3-Aminosalicylic acid, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Piktogramok

Exclamation mark
GHS07

Figyelmeztetés

Warning

Figyelmeztető mondatok

H315,H317,H319,H335

Veszélyességi osztályok

Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Célzott szervek

Respiratory system

Tárolási osztály kódja

11 - Combustible Solids

WGK

WGK 2

Lobbanási pont (F)

No data available

Lobbanási pont (C)

No data available

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Analitikai tanúsítványok (COA)

Lot/Batch Number

Sajnos jelenleg COA nem áll rendelkezésre ehhez a termékhez online.

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Dokumentumtár megtekintése

Alexander C Ford et al.
The American journal of gastroenterology, 106(12), 2070-2077 (2011-09-07)
Maintenance therapy with 5-aminosalicylates (5-ASAs) is recommended in patients with quiescent ulcerative colitis (UC), but compliance rates are low. Once-daily dosing may improve adherence, but impact on the relapse of disease activity is unclear as no previous meta-analysis has studied
A B Hawthorne et al.
Alimentary pharmacology & therapeutics, 27(12), 1157-1166 (2008-04-04)
Significant number of patients with ulcerative colitis (UC) fail to comply with treatment. To review issues surrounding medication non-adherence in inflammatory bowel disease (IBD), including the clinical and health service implications in the UK, and discuss strategies for optimizing medication
A Lyakhovich et al.
Alimentary pharmacology & therapeutics, 31(2), 202-209 (2009-11-07)
Mesalazine (mesalamine) (5-ASA) is considered an anti-inflammatory drug for the treatment of inflammatory bowel disease. It is well tolerated by most patients and induces mucosal healing specifically in ulcerative colitis. Besides its anti-inflammatory properties, 5-ASA has been studied for cancer
John K Marshall et al.
The Cochrane database of systematic reviews, (1)(1), CD004115-CD004115 (2010-01-22)
5-Aminosalicylates (5-ASA) are considered a first-line therapy for inducing and maintaining remission of mild to moderately active ulcerative colitis (UC). When inflammation in UC is limited to the distal colon, 5-ASA can also be administered rectally as a suppository, enema
M S Harris et al.
Alimentary pharmacology & therapeutics, 33(9), 996-1009 (2011-03-10)
The use of topical therapy in the treatment of ulcerative colitis has declined in recent years despite evidence of good efficacy. To review US prescription trends for 5-aminosalicylic acid (5-ASA) since the US approval of Asacol extended-release oral mesalazine (mesalamine)
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