A3537

5-Aminosalicylic acid

powder, ≥99%

• Szinonimák: 5-AS, 5-Amino-2-hydroxybenzoic acid, Mesalamine
• Lineáris képlet: H₂NC₆H₃-2-(OH)CO₂H
• CAS-szám: 89-57-6
• Molekulatömeg: 153.14
• Beilstein: 2090421
• EC-szám: 201-919-1
• MDL-szám: MFCD00007877
• UNSPSC kód: 12352204
• PubChem Substance ID: 24890780
• NACRES: NA.83

Tulajdonságok

• Terméknév: 5-Aminosalicylic acid, ≥99%
• Minőségi szint: 200
• Teszt: ≥99%
• Forma: powder
• szín: off-white to gray
• mp: 275-280 °C (dec.) (lit.)
• oldhatóság: 1 M HCl: 50 mg/mL, clear, yellow to brown
• tárolási hőmérséklet: 2-8°C
• SMILES string: Nc1ccc(O)c(c1)C(O)=O
• InChI: 1S/C7H7NO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,8H2,(H,10,11)
• Nemzetközi kémiai azonosító kulcs: KBOPZPXVLCULAV-UHFFFAOYSA-N
• Géninformáció: human ... ALOX5(240) , PPARG(5468) , PTGS1(5742) , PTGS2(5743)

Leírás

Alkalmazás

5-Aminosalicylic acid (5-ASA) has been used:

• to synthesize 5-formyl-aminosalicylate-inulin to quantify its release during in vitro digestion and fermentation and compare the in vitro fermentation properties of the conjugated inulin to native inulin
• in cell adhesion assay to study its effects on E-cadherin glycosylation and membranous turnover
• to evaluate its effects on the neutrophilic inflammation index (NII) phenotype to study the effectiveness of the high cholesterol diet-gut inflammation (HCD-GI) platform

5-Aminosalicylic acid is a peroxidase substrate suitable for use in ELISA procedures. This substrate produces a soluble end product that is brown in color and can be read spectrophotometrically at 450 nm. The reaction may be stopped with 3 N NaOH and read at 550 nm.

Biokémiai/fiziológiai hatások

5-Aminosalicylic acid (5-ASA) is a first-line medicine, used to treat inflammatory bowel diseases like ulcerative colitis (UC). It has a high-efficiency rate in maintenance and induction of remission. 5-ASA is an active component of sulfasalazine and also consists of the carbohydrate polymer, inulin. It might exhibit anti-oxidant activity to lessen tissue injury. 5-ASA is vital for the prevention of T cell activation and proliferation. It negatively regulates cyclooxygenase and lipoxygenase pathways and lowers the formation of prostaglandins and leukotrienes. 5-ASA stimulates the membranous expression of E-cadherin and boosts intercellular adhesion.

Biztonsági adatok

• Piktogramok: GHS07
• Figyelmeztetés: Warning
• Figyelmeztető mondatok: H315,H317,H319,H335
• Óvintézkedésre vonatkozó mondatok: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Veszélyességi osztályok: Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Célzott szervek: Respiratory system
• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 2
• Lobbanási pont (F): No data available
• Lobbanási pont (C): No data available
• Egyéni védőeszköz: dust mask type N95 (US), Eyeshields, Gloves