S0883

Sulfasalazine

97.0-101.5%

• Szinonimák: 2-Hydroxy-5-{{4-[(2-pyridinylamino)sulfonyl]phenyl}azo}benzoic acid, 5-[4-(2-Pyridylsulfamoyl)phenylazo]salicylic acid, Salicylazosulfapyridine
• Tapasztalati képlet (Hill-képlet): C₁₈H₁₄N₄O₅S
• CAS-szám: 599-79-1
• Molekulatömeg: 398.39
• Beilstein: 356241
• EC-szám: 209-974-3
• MDL-szám: MFCD00057363
• UNSPSC kód: 41116107
• PubChem Substance ID: 329824182
• NACRES: NA.24

Tulajdonságok

• Minőségi szint: 200
• Teszt: 97.0-101.5%
• Forma: powder
• technika/technikák: HPLC: suitable; gas chromatography (GC): suitable
• mp: 260-265 °C (dec.) (lit.)
• alkalmazás(ok): forensics and toxicology; pharmaceutical (small molecule)
• Hatásmechanizmus: DNA synthesis | interferes; enzyme | inhibits
• SMILES string: OC(=O)c1cc(ccc1O)\N=N\c2ccc(cc2)S(=O)(=O)Nc3ccccn3
• InChI: 1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+
• Nemzetközi kémiai azonosító kulcs: NCEXYHBECQHGNR-QZQOTICOSA-N
• Géninformáció: human ... ALOX5(240) , PTGS1(5742) , PTGS2(5743)

Leírás

Általános leírás

Chemical structure: sulfonamide

Sulfasalazine (SSZ) belongs to the sulfonamide class of drugs, which can be metabolized into 5-aminosalicylic acid and sulfapyridine. SSZ is obtained as a reaction product of an antibacterial agent (sulfapyridine) and an anti-inflammatory agent (salicylic acid).

Alkalmazás

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Sulfasalazine has been used as an analytical standard in clinical studies:

• For investigating its therapeutic potential in patients suffering from multiple sclerosis (MS).
• For studying its role as an antiarthritic agent via inhibition of the cartilage degeneration and pain associated with progression of osteoarthritis in the rat, which is used as the test animal.

It may also be used as an analytical reference standard for the quantification of the analyte in biological samples and aqueous samples using enzyme-linked immunosorbent assay (ELISA) and spectrofluorimetic technique.

Biztonsági adatok

• Piktogramok: GHS08,GHS09
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H317,H334,H351,H361f,H411
• Óvintézkedésre vonatkozó mondatok: P202 - P261 - P273 - P280 - P302 + P352 - P308 + P313
• Veszélyességi osztályok: Aquatic Chronic 2 - Carc. 2 - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1
• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 2
• Egyéni védőeszköz: dust mask type N95 (US), Eyeshields, Faceshields, Gloves