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Y0000049

Amlodipine besylate

European Pharmacopoeia (EP) Reference Standard

Szinonimák:

2-[(2-Aminoethoxy)-methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5- pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzene sulfonate, Norvasc

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About This Item

Tapasztalati képlet (Hill-képlet):
C20H25ClN2O5 · C6H5SO3H
CAS-szám:
111470-99-6
Molekulatömeg:
567.05
MDL-szám:
MFCD00887594
UNSPSC kód:
41116107
PubChem Substance ID:
329830828
NACRES:
NA.24

grade

pharmaceutical primary standard

API-család

amlodipine

gyártó/kereskedő neve

EDQM

alkalmazás(ok)

pharmaceutical (small molecule)

Formátum

neat

tárolási hőmérséklet

2-8°C

SMILES string

OS(=O)(=O)c1ccccc1.CCOC(=O)C2=C(COCCN)NC(C)=C(C2c3ccccc3Cl)C(=O)OC

InChI

1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9)

Nemzetközi kémiai azonosító kulcs

ZPBWCRDSRKPIDG-UHFFFAOYSA-N

Géninformáció

human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779)

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Általános leírás

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Alkalmazás

Amlodipine besylate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biokémiai/fiziológiai hatások

Amlodipine besylate is an L-type calcium channel blocker.
Amlodipine is an L-type calcium channel blocker. Amlodipine belongs to a class of cardiovascular drugs, which act at the voltage gated calcium channel of the CaV1, or L-type, class. Amlodipine also has antihypertensive and antianginal effects. Its activity resides mainly in the (-)-isomer. Amlodipine inhibits growth of human epidermoid carcinoma A431 cells and has antireproductive effects in male rats.

Kiszerelés

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Egyéb megjegyzések

Sales restrictions may apply.

kapcsolódó termék

Product No.
Leírás
Árazás

1029501

Amlodipine besylate, United States Pharmacopeia (USP) Reference Standard

Y0001068

Amlodipine impurity A, European Pharmacopoeia (EP) Reference Standard

Y0001069

Amlodipine impurity B, European Pharmacopoeia (EP) Reference Standard

Y0001070

Amlodipine impurity G, European Pharmacopoeia (EP) Reference Standard

Y0001067

Amlodipine for peak identification, European Pharmacopoeia (EP) Reference Standard

1029512

Amlodipine Related Compound A, United States Pharmacopeia (USP) Reference Standard

1029545

Amlodipine Related Compound D, United States Pharmacopeia (USP) Reference Standard

1029534

Amlodipine Related Compound C, United States Pharmacopeia (USP) Reference Standard

1029614

Amlodipine Related Compound K, United States Pharmacopeia (USP) Reference Standard

59872

2-[[2-[(2-Carboxybenzoyl)amino]ethoxy]methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester, reference material

51818

Diethyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate, reference material

PHR2050

Amlodipine Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2052

Amlodipine Related Compound C, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2051

Amlodipine Impurity B, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2053

Amlodipine Related Compound D, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2056

Amlodipine Related Compound K, Pharmaceutical Secondary Standard; Certified Reference Material

Piktogramok

Exclamation mark
GHS07

Figyelmeztetés

Warning

Figyelmeztető mondatok

H302

Óvintézkedésre vonatkozó mondatok

P264 - P270 - P301 + P312 - P501

Veszélyességi osztályok

Acute Tox. 4 Oral

Tárolási osztály kódja

11 - Combustible Solids

WGK

WGK 3

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Analitikai tanúsítványok (COA)

Lot/Batch Number

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Journal of the American Society of Hypertension : JASH, 7(1), 32-39 (2013-01-17)
The purpose of this study was to evaluate a fixed olmesartan/amlodipine combination on blood pressure control, lipid profile, insulin sensitivity, and some inflammatory markers compared with single-drug monotherapy. A total of 276 hypertensive patients were randomly assigned to olmesartan 20
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