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Merck

V0033000

Valproic acid

European Pharmacopoeia (EP) Reference Standard

Szinonimák:

2-Propylpentanoic acid, Valproic acid

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez


About This Item

Lineáris képlet:
(CH3CH2CH2)2CHCO2H
CAS-szám:
Molekulatömeg:
144.21
MDL-szám:
UNSPSC kód:
41116107
PubChem Substance ID:
NACRES:
NA.24
Az árazás és az elérhetőség jelenleg nem elérhető

grade

pharmaceutical primary standard

Ügynökség

EP Reference Standard

API-család

valproic acid

gyártó/kereskedő neve

EDQM

törésmutató

n20/D 1.425 (lit.)

bp

220 °C (lit.)

sűrűség

0.9 g/mL at 25 °C (lit.)

alkalmazás(ok)

pharmaceutical (small molecule)

Formátum

neat

tárolási hőmérséklet

2-8°C

SMILES string

CCCC(C(O)=O)CCC

InChI

1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)

Nemzetközi kémiai azonosító kulcs

NIJJYAXOARWZEE-UHFFFAOYSA-N

Géninformáció

human ... ALDH5A1(7915)

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Általános leírás

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Alkalmazás

Valproic acid EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biokémiai/fiziológiai hatások

Anticonvulsant that also has efficacy as a mood stabilizer in bipolar disorder

Kiszerelés

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Egyéb megjegyzések

Sales restrictions may apply.

Figyelmeztetés

Danger

Figyelmeztető mondatok

Veszélyességi osztályok

Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1A - Skin Irrit. 2

Tárolási osztály kódja

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Lobbanási pont (F)

231.8 °F - closed cup

Lobbanási pont (C)

111 °C - closed cup


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Analitikai tanúsítványok (COA)

Lot/Batch Number

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Dokumentumtár megtekintése

Periyasamy Palsamy et al.
Experimental eye research, 121, 26-34 (2014-02-15)
Recent epidemiological studies confirm the prevalence of cataract in epileptic patients. Similarly, the drugs used to treat epilepsy also show the connection with increased cataract formation. In this present study, we investigated the suppression of Nrf2/Keap1 dependent antioxidant protection through
Taylor Chomiak et al.
Neurotoxicology and teratology, 36, 57-66 (2012-09-13)
Autism spectrum disorder (ASD) is a behaviourally defined brain disorder affecting approximately 1 in 88 children. Many pathological studies have shown that ASD is frequently associated with grey and white matter changes that can be described by their deviations from
Yu-Fan Chuang et al.
Biochemical pharmacology, 88(3), 372-383 (2014-02-21)
Inflammation and vascular perturbations are increasingly implicated in the pathogenesis of neurodegenerative diseases. Prevailing evidence suggests that valproic acid (VPA), an antiepileptic and mood stabilizer, exhibits not only neuro-protective effects, but also anti-inflammatory effects in neurodegenerative diseases. However, the underlying
Florence I Roullet et al.
Neurotoxicology and teratology, 36, 47-56 (2013-02-12)
Valproic acid (VPA) is both an anti-convulsant and a mood stabilizer. Clinical studies over the past 40 years have shown that exposure to VPA in utero is associated with birth defects, cognitive deficits, and increased risk of autism. Two recent
Ivana Rosenzweig et al.
Neuroscience and biobehavioral reviews, 36(8), 1848-1856 (2012-06-02)
Neuropsychiatric medications that directly alter the epigenome, such as valproic acid, can under certain conditions reactivate critical developmental periods and thus impact adult neuroconnectivity. In animal models valproic acid was shown to inhibit the process of postnatal myelination and to

Questions

  1. Which is the concentration / density of Valproic acid? Does it come sterile? If not, which filters would you recommend using?

    1 answer
    1. This product is a neat or pure liquid with a density is 0.9 g/mL at 25 °C. This material is soluble in ethanol, chloroform, DMSO, and dimethyl formamide. The material is not sterile but may be filter sterilized. The appropriate filter membrane is dependent upon the selected solvent. Stock solutions diluted out to working concentration in aqueous buffers or media may be filtered using a cellulose-based filter membrane. Please see the link below to review compatibility information for various filter types:
      https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/analytical-chemistry/filtration/chemical-compatibility-of-filter-components

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