A6733

Auranofin

≥98% (HPLC), powder, leukocyte activation pathway inhibitor

• Szinonimák: 1-Thio-β-D-glucopyranosatotriethylphosphine gold-2,3,4,6-tetraacetate, 3,4,5-Triacetyloxy-6-(acetyloxymethyl) oxane-2-thiolate triethylphosphanium, SKF 39162
• Tapasztalati képlet (Hill-képlet): C₂₀H₃₄AuO₉PS
• CAS-szám: 34031-32-8
• Molekulatömeg: 678.48
• EC-szám: 251-801-9
• MDL-szám: MFCD00080759
• UNSPSC kód: 51111800
• PubChem Substance ID: 329770903
• NACRES: NA.77

Tulajdonságok

• product name: Auranofin, ≥98% (HPLC)
• Minőségi szint: 100
• Teszt: ≥98% (HPLC)
• form: powder
• oldhatóság: DMSO: ≥5 mg/mL
• kezdeményező: Prometheus
• tárolási hőmérséklet: room temp
• SMILES string: CCP(CC)(CC)=[Au]S[C@@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O
• InChI: 1S/C14H20O9S.C6H15P.Au/c1-6(15)19-5-10-11(20-7(2)16)12(21-8(3)17)13(14(24)23-10)22-9(4)18;1-4-7(5-2)6-3;/h10-14,24H,5H2,1-4H3;4-6H2,1-3H3;/q;;+1/p-1/t10-,11-,12+,13-,14+;;/m1../s1
• Nemzetközi kémiai azonosító kulcs: AUJRCFUBUPVWSZ-XTZHGVARSA-M

Leírás

Alkalmazás

Auranofin inhibits both leukocyte activation pathways at multiple sites and the release of inflammatory mediators from human macrophages, basophils, and pulmonary mast cells. Auranofin also inhibits 5-lipoxygenase in human neutrophils, IKB kinase (IKK) by modifying Cys-179 of the IKKβ subunit 5 and selenoenzyme thioredoxin reductase (TrxR) which is involved in the defense against oxidative stress. Auranofin is a disease-modifying antirheumatic drug (DMARD) and has been used to study the anti-proliferative effects against OVCAR-3 human ovarian carcinoma cells.

Biokémiai/fiziológiai hatások

Auranofin inhibits various leukocyte activation pathways at multiple sites. Auranofin inhibits the release of inflammatory mediators from human macrophages, basophils, and pulmonary mast cells. The compound also inhibits 5-lipoxygenase in human neutrophils. Auranofin is a disease-modifying antirheumatic drug (DMARD). The compound is a potent inhibitor of selenoenzyme thioredoxin reductase (TrxR), which is involved in defense against oxidative stress. Auranofin is an efficient inducer of mitochondrial membrane permeability transition pore in the presence of calcium ions related to its inhibition of mitochondrial thioredoxin reductase. Auranofin inhibits IKB kinase (IKK) by modifying Cys-179 of the IKKβ subunit 5.

Tulajdonságok és előnyök

This compound was developed by Prometheus. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Biztonsági adatok

• Piktogramok: GHS06,GHS08
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H301,H361
• Óvintézkedésre vonatkozó mondatok: P202 - P264 - P270 - P280 - P301 + P310 - P405
• Veszélyességi osztályok: Acute Tox. 3 Oral - Repr. 2
• Tárolási osztály kódja: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: dust mask type N95 (US), Eyeshields, Faceshields, Gloves