PHR1634

Exemestane

Pharmaceutical Secondary Standard; Certified Reference Material

• Szinonimák: Exemestane, 6-Methyleneandrosta-1,4-diene-3,17-dione
• Tapasztalati képlet (Hill-képlet): C₂₀H₂₄O₂
• CAS-szám: 107868-30-4
• Molekulatömeg: 296.40
• MDL-szám: MFCD00866994
• UNSPSC kód: 41116107
• PubChem Substance ID: 329823524
• NACRES: NA.24

Tulajdonságok

• grade: certified reference material; pharmaceutical secondary standard
• Minőségi szint: 300
• Ügynökség: traceable to USP 1269050
• API-család: exemestane
• Analitikai műbizonylat: current certificate can be downloaded
• kiszerelés: pkg of 1 g
• technika/technikák: HPLC: suitable; gas chromatography (GC): suitable
• alkalmazás(ok): pharmaceutical (small molecule)
• format: neat
• tárolási hőmérséklet: 2-8°C
• SMILES string: C[C@]12CC[C@H]3[C@@H](CC(=C)C4=CC(=O)C=C[C@]34C)[C@@H]1CCC2=O
• InChI: 1S/C20H24O2/c1-12-10-14-15-4-5-18(22)20(15,3)9-7-16(14)19(2)8-6-13(21)11-17(12)19/h6,8,11,14-16H,1,4-5,7,9-10H2,2-3H3/t14-,15-,16-,19+,20-/m0/s1
• Nemzetközi kémiai azonosító kulcs: BFYIZQONLCFLEV-DAELLWKTSA-N
• Géninformáció: human ... CYP19A1(1588)

Leírás

Általános leírás

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Exemestane is a steroidal anticancer drug, that belongs to the class of antiestrogens known as aromatase inhibitors. It is commonly used for the treatment of breast cancer.

Alkalmazás

Exemestane may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by chromatography.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biokémiai/fiziológiai hatások

Exemestane is a steroidal antiestrogen and irreversible aromatase inhibitor. Exemestane acts as a false substrate for the aromatase enzyme. Exemestane also prevents the conversion of androgens to estrogens and is used to treat estrogen-dependent breast cancer.

Analízis megjegyzés

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Egyéb megjegyzések

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Lábjegyzet

To see an example of a Certificate of Analysis for this material enter LRAC3262 in the slot below. This is an example certificate only and may not be the lot that you receive.

Biztonsági adatok

• Piktogramok: GHS08,GHS09
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H360,H411
• Óvintézkedésre vonatkozó mondatok: P201 - P202 - P273 - P280 - P308 + P313 - P391
• Veszélyességi osztályok: Aquatic Chronic 2 - Repr. 1B
• Tárolási osztály kódja: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable