PHR1187

Tretinoin

Pharmaceutical Secondary Standard; Certified Reference Material

• Szinonimák: Retinoic acid, ATRA, Tretinoin, Vitamin A acid, all-trans-Retinoic acid
• Tapasztalati képlet (Hill-képlet): C₂₀H₂₈O₂
• CAS-szám: 302-79-4
• Molekulatömeg: 300.44
• Beilstein: 2057223
• EC-szám: 206-129-0
• MDL-szám: MFCD00001551
• UNSPSC kód: 41116107
• PubChem Substance ID: 329823197
• NACRES: NA.24

Tulajdonságok

• grade: certified reference material; pharmaceutical secondary standard
• Minőségi szint: 300
• Ügynökség: traceable to Ph. Eur. T1850000; traceable to USP 1674004
• API-család: tretinoin
• Forma: solid
• Analitikai műbizonylat: current certificate can be downloaded
• technika/technikák: HPLC: suitable; gas chromatography (GC): suitable
• mp: 180-181 °C (lit.)
• alkalmazás(ok): food and beverages
• Formátum: neat
• tárolási hőmérséklet: -10 to -25°C
• SMILES string: CC1=C(\C=C\C(C)=C\C=C\C(C)=C\C(O)=O)C(C)(C)CCC1
• InChI: 1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
• Nemzetközi kémiai azonosító kulcs: SHGAZHPCJJPHSC-YCNIQYBTSA-N
• Géninformáció: human ... RARA(5914) , RARB(5915) , RARG(5916)

Leírás

Általános leírás

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards. Tretinoin is a medication used for the treatment of severe cystic acne. The drug acts by regulating epithelial cell growth and differentiation, sebum production, collagen synthesis and keratinization of the skin.

Alkalmazás

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Tretinoin may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.

Biokémiai/fiziológiai hatások

all−trans−Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells. Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA. Retinoic acid primes embryonic stem cells to become neurons.

Analízis megjegyzés

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Egyéb megjegyzések

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Lábjegyzet

To see an example of a Certificate of Analysis for this material enter LRAB7354 in the slot below. This is an example certificate only and may not be the lot that you receive.

Biztonsági adatok

• Piktogramok: GHS08,GHS07,GHS09
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H302,H315,H360FD,H410
• Óvintézkedésre vonatkozó mondatok: P202 - P264 - P273 - P301 + P312 - P302 + P352 - P308 + P313
• Veszélyességi osztályok: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 1B - Skin Irrit. 2
• Tárolási osztály kódja: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable