T1850000

Tretinoin

European Pharmacopoeia (EP) Reference Standard

• Szinonimák: Retinoic acid, ATRA, Tretinoin, Vitamin A acid, all-trans-Retinoic acid
• Tapasztalati képlet (Hill-képlet): C₂₀H₂₈O₂
• CAS-szám: 302-79-4
• Molekulatömeg: 300.44
• Beilstein: 2057223
• MDL-szám: MFCD00001551
• UNSPSC kód: 41116107
• PubChem Substance ID: 329826691
• NACRES: NA.24

Tulajdonságok

• biológiai forrás: synthetic
• grade: pharmaceutical primary standard
• Ügynökség: EP
• API-család: tretinoin
• form: solid
• gyártó/kereskedő neve: EDQM
• technika/technikák: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• mp: 180-181 °C (lit.)
• alkalmazás(ok): pharmaceutical (small molecule)
• format: neat
• tárolási hőmérséklet: 2-8°C
• SMILES string: CC1=C(\C=C\C(C)=C\C=C\C(C)=C\C(O)=O)C(C)(C)CCC1
• InChI: 1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
• Nemzetközi kémiai azonosító kulcs: SHGAZHPCJJPHSC-YCNIQYBTSA-N
• Géninformáció: human ... RARA(5914) , RARB(5915) , RARG(5916)

Leírás

Általános leírás

This product is provided as delivered and specified by the issuing pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the authority of the issuing pharmacopoeia. For further information and support please go to the website of the issuing pharmacopoeia.

Tretinoin is a medication used to treat a variety of skin conditions such as photodamaged skin, acne, etc. It is used as an anti-aging product and also as an oral treatment for leukemia.

Alkalmazás

This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia.

Biokémiai/fiziológiai hatások

all−trans−Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells. Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA. Retinoic acid primes embryonic stem cells to become neurons.

Kiszerelés

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Egyéb megjegyzések

Sales restrictions may apply.

Biztonsági adatok

• Piktogramok: GHS08,GHS07,GHS09
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H302,H315,H360FD,H410
• Óvintézkedésre vonatkozó mondatok: P202 - P264 - P273 - P301 + P312 - P302 + P352 - P308 + P313
• Veszélyességi osztályok: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 1B - Skin Irrit. 2
• Tárolási osztály kódja: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable