427218

FX11

≥96% (HPLC), solid, lactate dehydrogenase A inhibitor, Calbiochem^®

• Szinonimák: Lactate Dehydrogenase A Inhibitor, FX11
• Tapasztalati képlet (Hill-képlet): C₂₂H₂₂O₄
• CAS-szám: 213971-34-7
• Molekulatömeg: 350.41
• MDL-szám: MFCD00080561
• UNSPSC kód: 12352200
• NACRES: NA.54

Tulajdonságok

• Terméknév: Lactate Dehydrogenase A Inhibitor, FX11, Lactate Dehydrogenase A Inhibitor, FX11, CAS 213971-34-7, is a cell permeable, selective, reversible, NADH competitive inhibitor of lactate dehhydrogenase A (LDHA; Ki = 8 µM for human liver LDHA).
• Minőségi szint: 100
• Teszt: ≥96% (HPLC)
• Forma: solid
• hatékonyság: 8 μM K_i
• gyártó/kereskedő neve: Calbiochem^®
• tárolási körülmény: OK to freeze; protect from light
• szín: white
• oldhatóság: DMSO: 50 mg/mL
• kiszállítva: ambient
• tárolási hőmérséklet: 2-8°C

Leírás

Általános leírás

A cell permeable, gossypol analog that acts as a selective, reversible, and NADH competitive inhibitor of lactate dehhydrogenase A (LDHA; K_i = 8 µM for human liver LDHA). Does not affect the activities of LDHB and glyceraldehyde-3-phosphate dehydrogenase even at higher concentrations. Shown to increase oxygen consumption, reactive oxygen species production, and cell death in P493 human lymphoma B cells. Also shown to reduce mitochondrial transmembrane potential and ATP levels and increase AMP kinase activity. Exhibits synergistic toxicity in P493 cells when combined with FK866 (Cat. No. 481908). Blocks the progression of human lymphoma and pancreatic cancer xenografts and when used in combination with FK866 it induces lymphoma regression.

Alkalmazás

Lactate Dehydrogenase A Inhibitor, FX11, CAS 213971-34-7, is a cell permeable, selective, reversible, NADH competitive inhibitor of lactate dehhydrogenase A (LDHA; Ki = 8 µM for human liver LDHA).

Biokémiai/fiziológiai hatások

Cell permeable: yes

Primary Target
LDHA

Figyelmeztetés

Toxicity: Standard Handling (A)

Feloldás

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Egyéb megjegyzések

Le, A., et al. 2011. Proc Natl Acad Sci USA.107, 2037.
Deck, L. M., et al. 1998. J Med Chem.41, 3879.

Jogi információk

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable