393204

4-Hydroxynonenal

≥98% (HPLC), liquid, lipid peroxidation marker, Calbiochem^®

• Szinonimák: 4-Hydroxynonenal
• Tapasztalati képlet (Hill-képlet): C₉H₁₆O₂
• CAS-szám: 75899-68-2
• Molekulatömeg: 156.22
• UNSPSC kód: 12352114
• NACRES: NA.77

Tulajdonságok

• product name: 4-Hydroxynonenal, 4-Hydroxynonenal, CAS 75899-68-2, is a major aldehyde product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation.
• Minőségi szint: 100
• Teszt: ≥98% (HPLC)
• form: liquid
• gyártó/kereskedő neve: Calbiochem^®
• tárolási körülmény: OK to freeze
• oldhatóság: ethanol: 10 mg/mL
• tárolási hőmérséklet: −70°C
• InChI: 1S/C9H16O2/c1-2-3-4-6-9(11)7-5-8-10/h5,7-9,11H,2-4,6H2,1H3/b7-5+
• Nemzetközi kémiai azonosító kulcs: JVJFIQYAHPMBBX-FNORWQNLSA-N

Leírás

Általános leírás

4-Hydroxynonenal, CAS 75899-68-2, is a major aldehyde product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation.

A major aldehyde product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation. Inhibits proliferation and induces differentiation of HL-60 human leukemic cells. Also induces cell death in murine alveolar macrophages and in PC12 cells. An inhibitor of state 3 respiration at micromolar levels. Causes a transient increase in cytosolic Ca²⁺ and irreversibly inhibits Na⁺, K⁺-ATPase activity (IC₅₀ = 120 µM). Acts as a reversible inhibitor of c-Jun N-terminal kinase (JNK).

A major aldehydic product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation. Inhibits proliferation and induces differentiation of HL-60 human leukemic cells. Also induces cell death in murine alveolar macrophages. An inhibitor of State 3 respiration at micromolar levels that causes a transient increase in cytosolic Ca²⁺. Irreversibly inhibits Na⁺-K⁺-ATPase activity (IC₅₀ = 120 µM).

Biokémiai/fiziológiai hatások

Primary Target
Na⁺, K⁺-ATPase activity

Product does not compete with ATP.

Target IC₅₀: 120 µM against Na⁺, K⁺-ATPase activity

Figyelmeztetés

Toxicity: Flammable (J)

Fizikai forma

Supplied at 10 mg/ml in ethanol

Feloldás

Following initial thaw, aliquot and freeze (-70°C).

Egyéb megjegyzések

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Soh, Y., et al. 2000. Mol. Pharmacol.58, 535.
Carini, R., et al. 1996. Biochem. Biophys. Res. Commun.218, 772.
Li, L., et al. 1996. Toxicol.Appl. Pharmacol.139, 135.
Siems, W.G., et al. 1996. Free Radic. Res.20, 215.
Ullrich, O., et al. 1996. Free Radic. Res.24, 421.
van Kuijk, F.J., et al. 1995. Anal. Biochem. 224, 420.
Esterbauer, H., et al. 1991. Free Radic. Biol. Med.11, 81.

Jogi információk

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Biztonsági adatok

• Piktogramok: GHS02,GHS07
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H225,H319
• Óvintézkedésre vonatkozó mondatok: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Veszélyességi osztályok: Eye Irrit. 2 - Flam. Liq. 2
• Tárolási osztály kódja: 3 - Flammable liquids
• WGK: WGK 3
• Lobbanási pont (F): 57.2 °F - closed cup
• Lobbanási pont (C): 14 °C - closed cup