QBD10194

NHS-S-S-dPEG^®₄-biotin (cleavable)

• Szinonimák: 2,5-Dioxo-1-pyrrolidinyl 29-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-9,25-dioxo-12,15,18,21-tetraoxa-4,5-dithia-8,24-diazanonacosanoate, Polyethylene glycol
• Tapasztalati képlet (Hill-képlet): C₃₀H₄₉N₅O₁₁S₃
• CAS-szám: 1260247-51-5
• Molekulatömeg: 751.93
• UNSPSC kód: 51171641
• PubChem Substance ID: 329823886
• NACRES: NA.22

Tulajdonságok

• Teszt: >90%
• form: solid or viscous liquid
• reakcióalkalmasság: reaction type: Biotinylations; reagent type: cross-linking reagent
• funkcionális csoport: disulfide
• polimer felépítés: shape: linear; functionality: monofunctional
• kiszállítva: ambient
• tárolási hőmérséklet: −20°C
• SMILES string: O=C(NCCSSCCC(ON1C(CCC1=O)=O)=O)CCOCCOCCOCCOCCNC(CCCCC2C3NC(NC3CS2)=O)=O

Leírás

Tulajdonságok és előnyök

NHS-S-S-dPEG^®₄-biotin is used extensively to label molecules that contain a free amine with biotin. This dPEG^® spacer imparts a high degree of water solubility to the biotin label. For biotinylated peptides and proteins, the dPEG^® spacer dramatically reduces aggregation and precipitation of the modified molecule and reduces non-specific binding of the molecule, both of which are common problems with molecules that have been biotinylated with the widely used NHS-LC-biotin. NHS-S-S-dPEG^®₄-biotin contains a disulfide group in the linear chain, allowing the biotin to be cleaved reductively from the labeled molecule.

Jogi információk

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable