928321

BrettPhos Pd G3 ChemBeads

• Szinonimák: [(2-Di-cyclohexylphosphino-3,6-dimethoxy-2′,4′,6′- triisopropyl-1,1′-biphenyl)-2-(2′-amino-1,1′ -biphenyl)]palladium(II) methanesulfonate methanesulfonate
• Tapasztalati képlet (Hill-képlet): C₄₈H₆₆NO₅PPdS
• CAS-szám: 1470372-59-8
• Molekulatömeg: 906.50
• MDL-szám: MFCD22572666
• UNSPSC kód: 12352101
• NACRES: NA.82

Tulajdonságok

• Teszt: ~5 wt.% loading of catalyst
• Minőségi szint: 100
• Forma: solid
• reakcióalkalmasság: reagent type: catalyst; reaction type: Cross Couplings
• a címkézés mértéke: ~5 wt. % loading of catalyst
• SMILES string: [Pd+]c5c(cccc5)c6c(cccc6)N.P(C4CCCCC4)(C3CCCCC3)c1c(ccc(c1c2c(cc(cc2C(C)C)C(C)C)C(C)C)OC)OC.[S](=O)(=O)([O-])C

Leírás

Általános leírás

BrettPhos Pd G3 is a third generation (G3) Buchwald precatalyst. It is air, moisture and thermally-stable and is highly soluble in a wide range of common organic solvents. It has long life in solutions. BrettPhos Pd G3 is an excellent reagent for Buchwald-Hartwig cross-coupling reaction. Some of its unique features include lower catalyst loadings, shorter reaction time, efficient formation of the active catalytic species and accurate control of ligand: palladium ratio.

For larger scale uses, product also available in powdered form (761605)

Alkalmazás

BrettPhos Pd G3 may be used for the C-N coupling reaction between monosubstituted ureas and 1,2 dihaloaromatic system to form benzimidazolones.It may be used in the synthesis of following compounds:

• [Pd(cinnamyl)(BrettPhos)]OTf by reacting with [(cinnamyl)PdCl]₂ and AgOTf.
• [Pd(crotyl)(BrettPhos)]OTf by reacting with [(crotyl)PdCl]₂ and AgOTf.
• [Pd(allyl)(BrettPhos)]OTf by reacting with [(allyl)PdCl]₂ and AgOTf.
• Pd(allyl)(BrettPhos)Cl by reacting with [(allyl)PdCl]₂.

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Biztonsági adatok

• Piktogramok: GHS08
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H350i
• Óvintézkedésre vonatkozó mondatok: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Veszélyességi osztályok: Carc. 1B Inhalation
• Tárolási osztály kódja: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• WGK: WGK 3