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E1378

Escin

≥95%, powder

Sinónimos:

Aescin

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Número CAS:
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352201
EC Number:
229-880-6
MDL number:
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biological source

plant (Aesculus chinensis)

Quality Segment

assay

≥95%

form

powder

impurities

≤6.0% Water (Karl Fischer)

color

white

solubility

methanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

SMILES string

C\C=C(/C)C(=O)OC1[C@H](OC(C)=O)C2(CO)[C@H](O)C[C@]3(C)C(=CCC4C5(C)CCC(O[C@@H]6O[C@@H]([C@@H](O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O[C@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)C(O)=O)[C@](C)(CO)C5CCC34C)C2CC1(C)C

InChI

1S/C55H86O24/c1-10-23(2)46(71)79-43-44(72-24(3)60)55(22-59)26(17-50(43,4)5)25-11-12-30-51(6)15-14-32(52(7,21-58)29(51)13-16-53(30,8)54(25,9)18-31(55)61)75-49-41(77-48-38(67)36(65)34(63)28(20-57)74-48)39(68)40(42(78-49)45(69)70)76-47-37(66)35(64)33(62)27(19-56)73-47/h10-11,26-44,47-49,56-59,61-68H,12-22H2,1-9H3,(H,69,70)/b23-10+/t26?,27-,28-,29?,30?,31-,32?,33-,34-,35+,36+,37-,38-,39+,40+,41-,42+,43?,44+,47+,48-,49-,51?,52-,53?,54-,55?/m1/s1

InChI key

AXNVHPCVMSNXNP-YSYFQUGBSA-N

Application

Escin, a natural mixture of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, is used and studied as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent.[1] It may be used to study its pharmacokinetics, safety and efficacy as a chemosensitizer and modulator of NF-κ B cell signaling.[2]

Other Notes

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

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vibrant-m

PHL89871

Escin

Escin IA phyproof® Reference Substance

PHL80445

Escin IA

assay

≥95%

assay

≥75.0% (HPLC)

assay

≥94% (HPLC)

assay

≥90.0% (HPLC)

biological source

plant (Aesculus chinensis)

biological source

-

biological source

plant

biological source

-

solubility

methanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

solubility

-

solubility

H2O: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

solubility

-

Quality Level

200

Quality Level

-

Quality Level

200

Quality Level

-

form

powder

form

-

form

powder

form

-

impurities

≤6.0% Water (Karl Fischer)

impurities

-

impurities

≤12.5% water (Karl Fischer)

impurities

-


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pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 2

ppe

dust mask type N95 (US), Eyeshields, Gloves



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Número de artículo de comercio global

SKUGTIN
E1378-5G04061833601716
E1378-10G04061833601693
E1378-1G04061833601709

Questions

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  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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