SML2948

Mca-APK(Dnp)-OH trifluoroacetate

≥97% (HPLC), ACE2 substrate, film or powder

• Synonyme(s) : Mca-APK(Dnp) TFA salt (Mca = 7-Methoxycoumarin-4-yl; Dnp = 2,4-dinitrophenyl), Mca-Ala-Pro-Lys(Dnp) TFA salt, Mca-Ala-Pro-Lys(Dnp)-OH TFA salt
• Formule empirique (notation de Hill) : C₃₂H₃₆N₆O₁₂ · xC₂HF₃O₂
• Poids moléculaire : 696.66 (free base basis)
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥97% (HPLC)
• Form: film or powder
• Storage condition: desiccated

Propriétés

• Nom du produit: Mca-APK(Dnp)-OH trifluoroacetate, ≥97% (HPLC)
• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: film or powder
• storage condition: desiccated
• color: white to dark beige
• storage temp.: −20°C

Description

Biochem/physiol Actions

Mca-APK(Dnp)-OH is a widely used fluorescent substrate for angiotensin-converting enzyme 2 (ACE2 cleaves between P & K). Proteolytic cleavage separates 7-methoxycoumarin-4-acetyl (Mca) from the fluorescence-quenching group 2,4-dinitrophenyl (Dnp), resulting in increased Mca fluorescence (Ex: 320-328 nm, Em: 405-420 nm). The fluorescence increase over background upon Mca-APK(Dnp) cleavage is more than 14-fold higher than that of Mca-YVADAPK(Dnp), while only Mca-YVADAPK(Dnp), but not Mca-APK(Dnp), can also be used for assessing caspase-1 (ICE) activity.

Popular fluorescent substrate for angiotensin-converting enzyme 2 (ACE2).

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable