SML2944

Mca-YVADAPK(Dnp)-OH trifluoroacetate

≥97% (HPLC)

• Synonyme(s) : Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp), TFA salt, Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-OH, TFA salt, Mca-YVADAPK(Dnp), TFA salt (Mca = 7-Methoxycoumarin-4-yl; Dnp = 2,4-dinitrophenyl)
• Formule empirique (notation de Hill) : C₅₃H₆₄N₁₀O₁₉ · xC₂HF₃O₂
• Poids moléculaire : 1145.13 (free base basis)
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥97% (HPLC)
• Form: film or powder

Propriétés

• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: film or powder
• color: white to dark beige
• storage temp.: −20°C

Description

Biochem/physiol Actions

Mca-YVADAPK(Dnp)-OH is a widely used fluorescent substrate for caspase-1 (ICE cleaves between D & A) and angiotensin-converting enzyme 2 (ACE2 cleaves between P & K). Proteolytic cleavage separates 7-methoxycoumarin-4-acetyl (Mca) from the fluorescence-quenching group 2,4-dinitrophenyl (Dnp), resulting in increased Mca fluorescence (Ex: 320-328 nm, Em: 405-420 nm).

Popular fluorescent substrate for caspase-1 (ICE) and angiotensin-converting enzyme 2 (ACE2).

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable