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C1138

ι-Carrageenan

Predominantly iota carrageenan

Synonyme(s) :

Vegetable gelatin

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A propos de cet article

Numéro CAS:
UNSPSC Code:
12352201
NACRES:
NA.25
EC Number:
232-949-3
MDL number:
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biological source

algae (Eucheuma spinosum)

Quality Level

form

powder

color

beige

useful pH range

8.0 - 10.5

solubility

water: soluble ~5 g/L

storage temp.

room temp

SMILES string

[S](=O)(=O)([O-])O[C@H]1[C@H](O[C@H]([C@@H]([C@H]1O[C@H]4O[C@H]5[C@@H]([C@H](OC5)[C@H]4O[S](=O)(=O)[O-])O[C@@H]6O[C@@H]([C@@H]([C@@H]([C@H]6O)O)O[S](=O)(=O)[O-])CO)O)O[C@@H]2[C@@H]3OC[C@H]2O[C@@H]([C@@H]3O[S](=O)(=O)[O-])O)CO

InChI

1S/C24H38O31S4/c25-1-5-12(52-56(31,32)33)9(27)10(28)22(46-5)49-14-8-4-44-18(14)20(55-59(40,41)42)24(48-8)51-16-11(29)23(47-6(2-26)15(16)53-57(34,35)36)50-13-7-3-43-17(13)19(21(30)45-7)54-58(37,38)39/h5-30H,1-4H2,(H,31,32,33)(H,34,35,36)(H,37,38,39)(H,40,41,42)/p-4/t5-,6-,7-,8-,9-,10-,11-,12+,13+,14+,15+,16-,17+,18+,19-,20-,21+,22+,23+,24-/m1/s1

InChI key

QIDSWKFAPCTSKL-RRQHLKGPSA-J

General description

Carrageenans are mucopolysaccharides from the cell walls of the red algae. They are anionic linear polymers composed of 1,3α-1,4β-galactans having one (κ-), two (ι-) or three (λ-) sulfates per disaccharide unit. In ionic solutions, κ- and ι-carrageenans self-associate into helical structures that form rigid or flexible gels, respectively. λ-carrageenans do not form helices and are non-gelling. Carrageenans are used commercially as thickeners and stabilizing agents.

Application

Carrageenans are used to suppress immune response in vivo and in vitro via mechanisms believed to involve selective cytopathic effect on macrophages. As ι-, κ-,and λ-carrageenans have varying degress of sulfation, they may be studied comparatively for differences in protective, antiviral, and immunosuppression activities.
Carrageenans are used to suppress immune response in vivo and in vitro via mechanisms believed to involve selective cytopathic effect on macrophages.[1] As ι-, κ-, and λ-carrageenans have varying degrees of sulfation, they may be studied comparatively for differences in protective, antiviral, and immunosuppression activities.[2] ι-Carrageenan may be used to help define the role of carrageenan sulfation levels in physicochemical, biochemical, biological and pharmacological responses.

Preparation Note

Blended from various seaweeds to produce flexible gels.

Other Notes

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

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Cet article
C101322048W201502
biological source

algae (Eucheuma spinosum)

biological source

algae (red)

biological source

plant

biological source

synthetic

solubility

water: soluble ~5 g/L

solubility

-

solubility

H2O: soluble 5 mg/mL (hot)

solubility

-

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

300

form

powder

form

powder

form

powder

form

-

storage temp.

room temp

storage temp.

room temp

storage temp.

-

storage temp.

-

useful pH range

8.0 - 10.5

useful pH range

7.5-10.5 (1.5% in water)

useful pH range

-

useful pH range

-


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Classe de stockage

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type N95 (US)



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Consulter la Bibliothèque de documents



Ritsu Nishimura et al.
Journal of medical and dental sciences, 60(1), 1-8 (2013-08-07)
Various gelatinizers, which facilitate oral ingestion, are employed in patients with dysphagia. The purpose of this study was to histologically clarify the influence of various gelatinizers on the lung, using rats. We administered 0.2 ml/kg of 0.1% xanthangam, a 0.25%
Kihyuck Kwak et al.
PloS one, 9(5), e97232-e97232 (2014-05-13)
The licensed human papillomavirus (HPV) vaccines elicit type-restricted immunity but do not target cutaneous HPV types of the beta genus that are associated with non-melanoma skin cancer in immune-compromised patients, and it is unclear if these diverse types share a
Jalles A Batista et al.
Carbohydrate polymers, 99, 59-67 (2013-11-28)
The sulfated polysaccharide (PLS) fraction of Agardhiella ramosissima was characterized by microanalysis, infrared spectroscopy, NMR and gas-liquid-chromatography-mass-spectrometry. The main constituent of PLS was the ι carrageenan. The monosaccharide composition of the PLS showed galactose, 3,6-anhydrogalactose and 6-O-methylgalactose. The PLS (30



Numéro d'article de commerce international

RéférenceGTIN
C1138-100G04061833461266
C1138-1KG04061833461273

Questions

1–4 of 4 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. Where can I get information of molecular weight of this product?

    1 answer
    1. Iota-Carrageenan is considered to be a high molecular weight Carrageenan. The molecular weight of this product is not determined. However, one publication suggests an average molecular weight of 453 - 652 kDa for Carrageenans, in general. Please see the link below to review this article:
      https://pubmed.ncbi.nlm.nih.gov/11552743/#:~:text=The%20number%20average%20molecular%20weights,kDa%20based%20on%20RI%20data.

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  3. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  4. Do you have The I.D. results available? Thanks

    1 answer
    1. No formal identification tests are performed on product C1138. Please review the specification sheet for this chemical:
      https://www.sigmaaldrich.com/specification-sheets/365/983/C1138-BULK.pdf

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