The solubility is not determined for D1822 doxycycline monohydrate. An older lot 066M4022V did have a solubility specification for DMSO of 0.90 - 1.10 mg/ml. General information for the solubility of this material can be found online: Soluble in ethanol or methanol; Sparingly soluble in water; Soluble in dilute acids, alkali hydroxides, and dimethyl sulfoxide. The following article has information on the solubility of doxycycline in aqueous solution: https://www.sciencedirect.com/science/article/pii/S0022354915424694
D1822
Doxycycline monohydrate
Synonym(s):
6-Deoxy-5-oxytetracycline monohydrate, Doxycycline
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About This Item
Empirical Formula (Hill Notation):
C22H24N2O8 · H2O
CAS Number:
Molecular Weight:
462.45
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51284030
MDL number:
Pricing and availability is not currently available.
form
powder or crystals
Quality Level
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria, mycoplasma, parasites
mode of action
protein synthesis | interferes
storage temp.
−20°C
SMILES string
O.C[C@@H]1[C@H]2[C@H](O)[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C2C(=O)c4c(O)cccc14
InChI
1S/C22H24N2O8.H2O/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);1H2/t7-,10+,14+,15-,17-,22-;/m0./s1
InChI key
XQTWDDCIUJNLTR-CVHRZJFOSA-N
Gene Information
human ... MMP1(4312), MMP13(4322), MMP7(4316), MMP8(4317)
Application
- In yeast cells, doxycycline has been used in doxycycline-inducible system for overexpression of methyltransferase Hmt1 (hnRNP methyltransferase 1).
- It has been used in the doxycycline-inducible IFITM (interferon-induced transmembrane) cell lines.
- It has also been used as an antimicrobial agent.
Biochem/physiol Actions
Doxycycline is a semisynthetic tetracycline that is active against bacteria, mycoplasma and protozoan parasites. It inhibits the bacterial protein synthesis by inhibiting the interaction of aminoacyl-tRNA and the bacterial ribosome.[1]
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
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This Item | |||
|---|---|---|---|
| antibiotic activity spectrum Gram-negative bacteria, mycoplasma, Gram-positive bacteria, parasites | antibiotic activity spectrum - | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria, mycoplasma, parasites | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria |
| mode of action protein synthesis | interferes | mode of action - | mode of action protein synthesis | interferes | mode of action protein synthesis | interferes |
| Quality Level 200 | Quality Level - | Quality Level 200 | Quality Level 200 |
| form powder or crystals | form - | form powder | form - |
| storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. - |
| Gene Information human ... MMP1(4312), MMP13(4322), MMP7(4316), MMP8(4317) | Gene Information human ... MMP1(4312), MMP13(4322), MMP7(4316), MMP8(4317) | Gene Information - | Gene Information - |
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signalword
Warning
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 2
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The IFITM proteins inhibit HIV-1 infection.
Lu J, et al.
Journal of Virology, 85, 2126-2137 (2011)
Uninterpretable cerebrospinal fluid absorbance scan caused by doxycycline therapy.
Jan Miller
Annals of clinical biochemistry, 56(5), 619-622 (2019-06-07)
Yeast Hmt1 catalyses asymmetric dimethylation of histone H3 arginine 2 in vitro.
Li HT, et al.
The Biochemical Journal, 467, 507-515 (2015)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| D1822-500MG | 04061833560853 |
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What is the solubility ratio of doxycycline monohydrate D1822, and in what solvent should it be resuspended?
1 answer-
Helpful?
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Is Doxycycline monohydrate suitable for cell culture?
1 answer-
This product has not been tested specifically for cell culture applications and has not been tested for endotoxin. However, a review of the peer-reviewed papers indicates that this material has been used successfully in cell culture studies. Please see the link below to review the peer-reviewed articles:
https://www.sigmaaldrich.com/search/d1822?focus=papers&page=1&perpage=30&sort=relevance&term=D1822&type=citation_searchHelpful?
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