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D5919

Diacylglycerol Kinase Inhibitor I

solid

Synonyme(s) :

6-[2-[4-[(4-Fluorophenyl)phenylmethylene]-1-piperidin­yl]ethyl]-7-methyl-5H-thiazolo-[3,2-a]-pyrimidin-5-one, R59022

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A propos de cet article

Formule empirique (notation de Hill) :
C27H26FN3OS
Numéro CAS:
93076-89-2
Poids moléculaire :
459.58
NACRES:
NA.77
PubChem Substance ID:
24893986
UNSPSC Code:
41106300
MDL number:
MFCD00055114
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
200
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biological source

synthetic (organic)

Quality Level

200

assay

≥98% (HPLC)

form

solid

color

pale yellow

solubility

0.1 M HCl: slightly soluble, 0.1 M NaOH: slightly soluble, DMSO: soluble, H2O: insoluble, ethanol: soluble, ethyl acetate: soluble

storage temp.

−20°C

SMILES string

CC1=C(CCN2CCC(\CC2)=C(\c3ccccc3)c4ccc(F)cc4)C(=O)N5C=CSC5=N1

InChI

1S/C27H26FN3OS/c1-19-24(26(32)31-17-18-33-27(31)29-19)13-16-30-14-11-22(12-15-30)25(20-5-3-2-4-6-20)21-7-9-23(28)10-8-21/h2-10,17-18H,11-16H2,1H3

InChI key

MFVJXLPANKSLLD-UHFFFAOYSA-N

General description

Diacylglycerol Kinase Inhibitor I prevents the formation of foreign body giant cell (FBGC).[1] It inhibits the phosphorylation of diacylglycerol to phosphatidic acid. Diacylglycerol Kinase Inhibitor I functions as a serotonin (5-HT) receptor (5-HTR) antagonist.[2] It stimulates apoptosis and autophagy in neuronal cell line NG108-15.[3]

Application

Diacylglycerol Kinase Inhibitor I has been used as an inhibitor to study suppression of T cell function using advanced generation human CAR (chimeric antigen receptors) T cells.

Biochem/physiol Actions

Diacylglycerol kinase inhibitor. Inhibits formation of [38P]1-Oleoxyl-2-acetylglyceryl-3-phosphoric acid (OAPA) in red blood cell membranes: IC50 = 3.3 μM.

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Cet article
266785266788D5794
Diacylglycerol Kinase Inhibitor I solid

Sigma-Aldrich

D5919

Diacylglycerol Kinase Inhibitor I

Diacylglycerol Kinase Inhibitor I The Diacylglycerol Kinase Inhibitor I, also referenced under CAS 93076-89-2, controls the biological activity of Diacylglycerol Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

266785

Diacylglycerol Kinase Inhibitor I

Diacylglycerol Kinase Inhibitor II The Diacylglycerol Kinase Inhibitor II, also referenced under CAS 120166-69-0, controls the biological activity of Diacylglycerol KInase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

266788

Diacylglycerol Kinase Inhibitor II

Diacylglycerol Kinase Inhibitor II solid

Sigma-Aldrich

D5794

Diacylglycerol Kinase Inhibitor II

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥97% (HPLC)

form

solid

form

solid

form

solid

form

solid

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

200

storage temp.

−20°C

storage temp.

10-30°C

storage temp.

10-30°C

storage temp.

−20°C

solubility

0.1 M HCl: slightly soluble, DMSO: soluble, ethanol: soluble, H2O: insoluble, 0.1 M NaOH: slightly soluble, ethyl acetate: soluble

solubility

ethanol: 12 mg/mL, DMSO: 4 mg/mL

solubility

DMSO: 12.5 mg/mL

solubility

0.1 M HCl: slightly soluble, 0.1 M NaOH: slightly soluble, DMSO: soluble, H2O: insoluble, ethanol: soluble, ethyl acetate: soluble

color

pale yellow

color

white

color

white

color

pale yellow

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Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
0000512519
0000512509
0000512509
0000512519
0000478843

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Multifactorial T-cell hypofunction that is reversible can limit the efficacy of chimeric antigen receptor-transduced human T cells in solid tumors
Moon EK, et al.
Clinical Cancer Research, 197-201 (2014)
Eric Ruelland et al.
Plant physiology, 130(2), 999-1007 (2002-10-12)
The signaling events generated by a cold exposure are poorly known in plants. We were interested in checking the possible activation of enzymes of the phosphoinositide signaling pathway in response to a temperature drop. In Arabidopsis suspension cells labeled with
Amy K McNally et al.
The American journal of pathology, 163(3), 1147-1156 (2003-08-26)
Multinucleated foreign body giant cells (FBGCs) form by monocyte-derived macrophage fusion on implanted biomedical devices and are believed to mediate oxidative damage to biomaterial surfaces. Our in vitro system of human macrophage culture and interleukin (IL)-4-induced FBGC formation was developed
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Numéro d'article de commerce international

RéférenceGTIN
D5919-1MG04061826674550
D5919-5MG04061833261446

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