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39286

Hydroxystilbamidine bis(methanesulfonate)

Name: Hydroxystilbamidine bis(methanesulfonate)
Brand: SIGMA

suitable for fluorescence, ≥96.0% (HPLC)

Synonyme(s) :

2-Hydroxystilbene-4,4′-dicarboxamidine bis(methanesulfonate), Fluoro-Gold

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Conditionnement	Référence	Disponibilité	Prix

A propos de cet article

Formule empirique (notation de Hill) :

C₁₈H₂₄N₄O₇S₂

Numéro CAS:

223769-64-0

Poids moléculaire :

472.54

NACRES:

NA.32

PubChem Substance ID:

57649893

UNSPSC Code:

41116100

MDL number:

MFCD01863083

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Propriétés

Quality Level

100

assay

≥96.0% (HPLC)

form

powder

fluorescence

λ_ex 318 nm; λ_em 560 nm in TBE Buffer

suitability

suitable for fluorescence

storage temp.

2-8°C

SMILES string

CS(O)(=O)=O.CS(O)(=O)=O.NC(=N)c1ccc(cc1)\C=C\c2ccc(cc2O)C(N)=N

InChI

1S/C16H16N4O.2CH4O3S/c17-15(18)12-5-2-10(3-6-12)1-4-11-7-8-13(16(19)20)9-14(11)21;2*1-5(2,3)4/h1-9,21H,(H3,17,18)(H3,19,20);2*1H3,(H,2,3,4)/b4-1+;;

InChI key

YGNSQKCULHSJDC-HFPMQDOPSA-N

Description

General description

Hydroxystilbamidine bis (methanesulfonate), also known as Fluoro-Gold, is a retrograde fluorescent tracer. Chemically, Hydroxystilbamidine is a weak base and can cross cell membranes in its uncharged form.[1]

A few properties of Hydroxystilbamidine bis (methanesulfonate) are:[2]

Intense Fluorescence.
Extensive filling of dendrites.
High Resistance to fading.
No uptake by undamaged fibers.
No diffusion from labelled cells.
Highly compatible with other neuro-histochemical techniques.

Application

Hydroxystilbamidine bis(methanesulfonate), a fluorescent retrograde tracer (axonal transport), is used for neural mapping in microanatomical research.

Hydroxystilbamidine bis (methanesulfonate) or Fluoro-Gold (FG) is used to label neurons and investigate the early effects of hearing loss.[3] It is used to study morphological features of extensive axonal projections within the CNS by labelling the cells.

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Cet article	A4108	67455	52595
Sigma-Aldrich 39286 Hydroxystilbamidine bis(methanesulfonate)	Sigma-Aldrich A4108 Aminophenyl fluorescein solution	Sigma-Aldrich 67455 Atto 514 NHS ester	Sigma-Aldrich 52595 Atto 514
suitability suitable for fluorescence	suitability suitable for fluorescence	suitability suitable for fluorescence	suitability suitable for fluorescence
fluorescence λ_ex 318 nm; λ_em 560 nm in TBE Buffer	fluorescence -	fluorescence λ_ex 511 nm; λ_em 533 nm±10 nm in PBS, pH 7.4	fluorescence λ_ex 511 nm; λ_em 533 nm±10 nm in PBS, pH 7.4
form powder	form liquid	form solid	form solid
assay ≥96.0% (HPLC)	assay -	assay 90% (Coupling efficiency with benzylamine, HPLC)	assay ≥90.0% (HPLC)
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. −20°C
Quality Level 100	Quality Level 200	Quality Level -	Quality Level -

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Musculotopic organization of the motor neurons supplying the mouse hindlimb muscles: a quantitative study using Fluoro-Gold retrograde tracing.

Tímea Bácskai et al.

Brain structure & function, 219(1), 303-321 (2013-01-05)

We have mapped the motor neurons (MNs) supplying the major hindlimb muscles of transgenic (C57/BL6J-ChAT-EGFP) and wild-type (C57/BL6J) mice. The fluorescent retrograde tracer Fluoro-Gold was injected into 19 hindlimb muscles. Consecutive transverse spinal cord sections were harvested, the MNs counted

Synaptic innervation to rat hippocampus by vasopressin-immuno-positive fibres from the hypothalamic supraoptic and paraventricular nuclei.

L Zhang et al.

Neuroscience, 228, 139-162 (2012-10-23)

The neuropeptide arginine vasopressin (AVP) exerts a modulatory role on hippocampal excitability through vasopressin V(1A) and V(1B) receptors. However, the origin and mode of termination of the AVP innervation of the hippocampus remain unknown. We have used light and electron

Fluoro-Gold: composition, and mechanism of uptake.

M W Wessendorf

Brain research, 553(1), 135-148 (1991-07-05)

Determining the mechanism by which fluorescent retrograde neuronal tracers are taken up requires knowledge of their composition. It has been claimed that Fluoro-Gold, a retrogradely transported fluorescent neuronal tracer, is 2-hydroxy-4,4'-diamidinostilbene (hydroxystilbamidine), an amidine antibiotic. However, this appears questionable, since

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Numéro d'article de commerce international

Référence	GTIN
39286-10MG-F	04061831981759

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