Unfortunately, the solution stability of this product is not determined.
F6020
Fenofibrate
≥99% (TLC), powder, PPARα agonist
Synonym(s):
2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoic acid isopropyl ester
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About This Item
Empirical Formula (Hill Notation):
C20H21ClO4
CAS Number:
Molecular Weight:
360.83
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
256-376-3
MDL number:
Pricing and availability is not currently available.
Product Name
Fenofibrate, ≥99%, powder
Quality Level
assay
≥99%
form
powder
color
off-white
originator
Abbott
storage temp.
room temp
SMILES string
CC(C)OC(=O)C(C)(C)Oc1ccc(cc1)C(=O)c2ccc(Cl)cc2
InChI
1S/C20H21ClO4/c1-13(2)24-19(23)20(3,4)25-17-11-7-15(8-12-17)18(22)14-5-9-16(21)10-6-14/h5-13H,1-4H3
InChI key
YMTINGFKWWXKFG-UHFFFAOYSA-N
Gene Information
human ... PPARA(5465)
Application
Fenofibrate has been used:
- to study its effect on plasma lipids, liver phenotype and gene expression
- to study its impact on endothelium-dependent vasodilatation of thoracic aorta[1]
- to administer to NASH knock-in mice along with a high fat diet (HFD) to study its effect
Biochem/physiol Actions
Fenofibrate increases high density lipoprotein levels by reducing cholesteryl ester transfer protein expression. It is used in treating the condition of increased cholesterol levels in the blood, abnormal lipid levels in the body and also hypertriglyceridaemia. Fenofibrate is a lipid regulating drug and proliferator-activated receptor-α (PPARα) mediates its action. It decreases the plasma levels of fibrinogen and C-reactive protein. By this fenofibrate allows better flow-mediated dilatation and reduces the risk of atherosclerosis. Fenofibrate is also known to reduce uric acid levels.
Features and Benefits
This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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| form powder | form - | form - | form - |
| assay ≥99% | assay - | assay - | assay - |
| Quality Level 100 | Quality Level 300 | Quality Level - | Quality Level - |
| storage temp. room temp | storage temp. 2-8°C | storage temp. - | storage temp. - |
| color off-white | color - | color - | color - |
| originator Abbott | originator - | originator - | originator - |
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signalword
Warning
hcodes
pcodes
Hazard Classifications
STOT RE 2 Oral
target_organs
Liver
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Oshri Avraham et al.
eLife, 10 (2021-09-30)
Sensory neurons with cell bodies in dorsal root ganglia (DRG) represent a useful model to study axon regeneration. Whereas regeneration and functional recovery occurs after peripheral nerve injury, spinal cord injury or dorsal root injury is not followed by regenerative
Intrahepatic cholesterol influences progression, inhibition and reversal of non-alcoholic steatohepatitis in hyperlipidemic mice
Wouters K, et al.
Febs Letters, 584(5), 1001-1005 (2010)
Fenofibrate
Keating GM and Croom KF
Drugs, 67(1), 121?153-121?153 (2012)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| F6020-25G | 04061833618417 |
| F6020-100G | 04061833057629 |
| F6020-5G | 04061833618424 |
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How should F6020 be stored for long term after resuspending in DMSO?
1 answer-
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Can F6020, Fenofibrate be used for cell culture assays?
1 answer-
This product is not tested for tissue culture applications. Refer to the Certificate of Analysis for release specifications.
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Could you provide the solubility information for item F6020, Fenofibrate?
1 answer-
Fenofibrate is soluble in acetone, ether, DMSO (15 mg/ml), DMF (30 mg/ml), ethanol (1 mg/ml), methanol (slightly soluble), benzene, chloroform, DMF:PBS (1:3 pH 7.2) (0.25 mg/ml), ethyl acetate, acetonitrile, and hexane. However, it is insoluble in water.
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