186562

Tetra-hidrofurano

≥99.9%, anhydrous, contains 250 ppm BHT as inhibitor

• Sinônimo(s): Oxolano, Óxido de butileno, Óxido de tetrametileno
• Fórmula empírica (Notação de Hill): C₄H₈O
• Número CAS: 109-99-9
• Peso molecular: 72.11
• Beilstein: 102391
• Número CE: 203-726-8
• Número MDL: MFCD00005356
• Código UNSPSC: 12191501
• ID de substância PubChem: 57647757
• NACRES: NA.21

Propriedades

• product name: Tetra-hidrofurano, anhydrous, contains 250 ppm BHT as inhibitor, ≥99.9%
• grau: anhydrous
• Nível de qualidade: 200
• densidade de vapor: 2.5 (vs air)
• pressão de vapor: 114 mmHg ( 15 °C); 143 mmHg ( 20 °C)
• Ensaio: ≥99.9%
• forma: liquid
• temperatura de autoignição: 610 °F
• contém: 250 ppm BHT as inhibitor
• Lim. expl.: 1.8-11.8 %
• Impurezas: ≤0.005% peroxides (as H₂O₂); <0.002% water (All units except 100 mL); <0.005% water (100 mL pkg)
• índice de refração: n20/D 1.407 (lit.)
• pH: ~7
• pb: 65-67 °C (lit.)
• pf: −108 °C (lit.)
• solubilidade: H₂O: soluble
• densidade: 0.889 g/mL at 25 °C (lit.)
• cadeia de caracteres SMILES: C1CCOC1
• InChI: 1S/C4H8O/c1-2-4-5-3-1/h1-4H2
• chave InChI: WYURNTSHIVDZCO-UHFFFAOYSA-N

Descrição

Descrição geral

Tetrahydrofuran (THF) is a saturated cyclic ether mainly used as an organic solvent. On long term storage it forms organic peroxides. This process can be suppressed by adding butylated hydroxytoluene (BHT) as a stabilizer. BHT removes the free radicals required for the peroxide formation. It constitutes the key fragment of various natural products (polyether antibiotics). THF forms double hydrate with hydrogen sulfide, crystal structure of this double hydrate has been investigated by three-dimensional single-crystal studies.

Aplicação

Dry tetrahydrofuran (THF) has been used in the synthesis of dichloro{bis[1,1′,1′′-(phosphinetriyl)tripiperidine]}palladium [(P(NC₅H₁₀)₃)₂Pd(Cl)₂], which is widely used in the Heck reaction as a catalyst. It has been employed in the reaction medium of the Heck cross-coupling reaction of various aryl bromides and olefins.

Embalagem

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Outras notas

Greener alternatives are available for many THF applications, 2-Methyltetrahydrofuran (414247) and Cyclopentyl methyl ether (675970)

Informações de segurança

• Pictogramas: GHS02,GHS08,GHS07
• Palavra indicadora: Danger
• Frases de perigo: H225,H302,H319,H335,H336,H351
• Declarações de precaução: P202 - P210 - P233 - P301 + P312 - P305 + P351 + P338 - P308 + P313
• Classificações de perigo: Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
• Órgãos-alvo: Central nervous system, Respiratory system
• Perigos de suplementos: EUH019
• Código de classe de armazenamento: 3 - Flammable liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): -6.2 °F - closed cup
• Ponto de fulgor (°C): -21.2 °C - closed cup
• Equipamento de proteção individual: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter