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KB-R7943

Name: KB-R7943
Brand: SIGMA

≥98% (HPLC), powder

Synonym(s):

2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester, methanesulfonate (1:1), Carbamimidothioic acid

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₇N₃O₃S·CH₃SO₃H

CAS Number:

182004-64-4

Molecular Weight:

427.50

NACRES:

NA.77

PubChem Substance ID:

329817144

UNSPSC Code:

12352200

MDL number:

MFCD00952138

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Pricing and availability is not currently available.

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Properties

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

off-white to tan

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

CS(O)(=O)=O.NC(=N)SCCc1ccc(OCc2ccc(cc2)[N+]([O-])=O)cc1

InChI

1S/C16H17N3O3S.CH4O3S/c17-16(18)23-10-9-12-3-7-15(8-4-12)22-11-13-1-5-14(6-2-13)19(20)21;1-5(2,3)4/h1-8H,9-11H2,(H3,17,18);1H3,(H,2,3,4)

InChI key

WGIKEBHIKKWJLG-UHFFFAOYSA-N

Description

Biochem/physiol Actions

KB-R7943 inhibits the reversed Na(+)/Ca(2+) exchanger, NCX.

KB-R7943 inhibits the reversed Na(+)/Ca(2+) exchanger, NCX. In cardiomyocytes, Ca2+ is released from intracellular stores during contraction, and sequestered again during relaxation. NCX is the primary mechanism that prevents Ca2+ overload due to influx of calcium across the plasma membrane.

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This Item	R1033	SML0378	SML2281
Sigma-Aldrich K4144 KB-R7943	Sigma-Aldrich R1033 RN-1747	Sigma-Aldrich SML0378 Ralfinamide mesylate	Sigma-Aldrich SML2281 BAY 60-2770
form powder	form powder	form powder	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level -
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: >10 mg/mL	solubility DMSO: ≥10 mg/mL	solubility H₂O: >15 mg/mL	solubility DMSO: 2 mg/mL, clear
color off-white to tan	color light yellow to light tan	color white to beige	color white to beige

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Activity dependent internalization of the glutamate transporter GLT-1 requires calcium entry through the NCX sodium/calcium exchanger.

Ignacio Ibáñez et al.

Neurochemistry international, 123, 125-132 (2018-03-27)

GLT-1 is the main glutamate transporter in the brain and its trafficking controls its availability at the cell surface, thereby shaping glutamatergic neurotransmission under physiological and pathological conditions. Extracellular glutamate is known to trigger ubiquitin-dependent GLT-1 internalization from the surface

The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells.

Camille Loubiere et al.

Scientific reports, 7(1), 5040-5040 (2017-07-13)

Mitochondrial integrity is critical for the regulation of cellular energy and apoptosis. Metformin is an energy disruptor targeting complex I of the respiratory chain. We demonstrate that metformin induces endoplasmic reticulum (ER) stress, calcium release from the ER and subsequent

TRPM5-mediated calcium uptake regulates mucin secretion from human colon goblet cells.

Sandra Mitrovic et al.

eLife, 2, e00658-e00658 (2013-06-07)

Mucin 5AC (MUC5AC) is secreted by goblet cells of the respiratory tract and, surprisingly, also expressed de novo in mucus secreting cancer lines. siRNA-mediated knockdown of 7343 human gene products in a human colonic cancer goblet cell line (HT29-18N2) revealed

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Global Trade Item Number

SKU	GTIN
K4144-5MG	04061833944691
K4144-25MG	04061833944684

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