In solution, this material does not require handling in a fume hood. As a general practice, gloves and eye protection are recommended. This product is not considered to be a hazardous material. Please review the Product Safety Data Sheet at the link below:
https://www.sigmaaldrich.com/sds/sigma/a2661?userType=red
A2661
Acetylcholine chloride
suitable for cell culture
Synonym(s):
ACh
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About This Item
Linear Formula:
(CH3)3N+CH2CH2OCOCH3Cl-
CAS Number:
Molecular Weight:
181.66
NACRES:
NA.75
PubChem Substance ID:
eCl@ss:
32190102
UNSPSC Code:
12352209
EC Number:
200-468-8
MDL number:
Beilstein/REAXYS Number:
3571875
Biological source:
synthetic
Form:
powder
Assay:
~99%
Pricing and availability is not currently available.
biological source
synthetic
Quality Level
assay
~99%
form
powder
technique(s)
cell culture | mammalian: suitable
mp
146-150 °C (lit.)
solubility
water: 100 mg/mL, clear, colorless
shipped in
ambient
storage temp.
room temp
SMILES string
[Cl-].CC(=O)OCC[N+](C)(C)C
InChI
1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1
InChI key
JUGOREOARAHOCO-UHFFFAOYSA-M
Gene Information
human ... CHRM3(1131)
Application
Acetylcholine chloride has been used in the preparation of acetylcholine, that is used as a common vehicle for iontophoresis of acetylcholine (ACh). It has also been used to treat aNS-1 derived neurons for cAMP (cyclic adenosine monophosphate) assay and also used to check their ability to influence G protein-coupled receptors (GPCRs).
Biochem/physiol Actions
Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis . The cholinergic anti-inflammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.
Endogenous neurotransmitter at cholinergic synapses; amplifies action potential of the sarcolemma thereby inducing muscle contractions.
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This Item | |||
|---|---|---|---|
| biological source synthetic | biological source - | biological source - | biological source - |
| assay ~99% | assay - | assay ≥99% (TLC) | assay - |
| Quality Level 200 | Quality Level 300 | Quality Level 100 | Quality Level - |
| form powder | form - | form powder or crystals | form - |
| technique(s) cell culture | mammalian: suitable | technique(s) HPLC: suitable, gas chromatography (GC): suitable | technique(s) - | technique(s) - |
| storage temp. room temp | storage temp. 2-8°C | storage temp. room temp | storage temp. −20°C |
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Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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A novel gel based vehicle for the delivery of acetylcholine in quantitative sudomotor axon reflex testing
Sletten D M, et al.
Autonomic Neuroscience : Basic & Clinical, 150(1-2), 127-130 (2009)
Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates
Garavaglia A, et al.
BMC Neuroscience, 11(1), 7-7 (2010)
Yue-Chen Chang et al.
Kidney & blood pressure research, 43(5), 1607-1622 (2018-10-23)
This experimental study aims to observe whether the protective effect of propofol against renal ischemia-reperfusion injury (IRI) in the rat interlobar artery occurs through altered expression of the gap junction protein connexin 43 (Cx43). This study randomly divided male Sprague
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A2661-100G | 04061833359617 |
| A2661-25G | 04061833359624 |
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Hi, is the reconstituted product safe to be used without any special precautions under a biological hood?
1 answer-
Helpful?
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Hello, I would like to ask the difference between Acetylcholine A6625 vs A2661. I am planinig to use in cardiovascular research. Could I learn the exact difference between them? Thank you
1 answer-
Product A2661 is tested for the suitability of cell culture applications. Please see the product specification sheet to view the testing done on this product:
https://www.sigmaaldrich.com/specification-sheet/SIGMA/A2661Product A6625 is not tested for the suitability of cell culture applications. Please see the specification sheet to view the testing done on this product:
https://www.sigmaaldrich.com/specification-sheet/SIGMA/A6625Helpful?
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How should a solution of Acetylcholine chloride be stored?
1 answer-
The reconstituted solution is stable for 2 weeks when stored at 2-8°C.
Helpful?
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